USA flag logo/image

An Official Website of the United States Government

Rapid and On-site Monitoring of Urinary Arsenic Metabolites

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
Program Year/Program:
2012 / SBIR
Agency Tracking Number:
R43ES022313
Solicitation Year:
2012
Solicitation Topic Code:
NIEHS
Solicitation Number:
ES12-004
Small Business Information
Giner
89 Rumford Avenue Newton, MA 02466-1311
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2012
Title: Rapid and On-site Monitoring of Urinary Arsenic Metabolites
Agency: HHS
Contract: 1R43ES022313-01
Award Amount: $249,570.00
 

Abstract:

DESCRIPTION (provided by applicant): Giner, Inc. proposes a portable, inexpensive, and rapid-response monitor for arsenic speciation in urine. Arsenic species excreted in urine are reflective of human exposure to toxic arsenic, and therefore this sensor will be a valuable biomonitoring tool in medical diagnostics and epidemiological studies by allowing determination of arsenic exposure faster and less expensive than traditional methods. Improved capability of monitoring exposure will have positive public health outcomes, as chronic exposure to arsenic is associated with health problems including cancer and cardiovascular disease. The Phase I program will develop a monitor prototype capable of direct electrochemical detection of arsenic (III) in urine with anadvanced electrode substrate. Quantification of other important arsenic species and metabolites (arsenic [V] and mono- and dimethyl arsinate) will be performed by sequential and rapid conversion to arsenic (III) via chemical and electrochemical methods toobtain the total amount of toxic arsenic in urine. The phase I program feasibility studies will include validation of the alpha prototype with real urine samples from epidemiological studies. The phase II program will result in a practical, robust, and highly accurate device capable of on-site analysis. PUBLIC HEALTH RELEVANCE: A portable, inexpensive, and rapid-response monitor for speciation analysis of inorganic arsenic and arsenic metabolites species in urine is proposed. Traditional methods of assessing arsenic exposure are time-intensive and cost-prohibitive, and therefore such low cost onsite monitor will have positive public health outcomes by improving ability to monitor arsenic exposure in at-risk populations.

Principal Investigator:

Badawi M. Dweik
(781) 529-0520
bdweik@ginerinc.com

Business Contact:

Anthony J. Vaccaro
(781) 529-0504
avaccaro@ginerinc.com
Small Business Information at Submission:

GINER, INC.
89 RUMFORD AVENUE NEWTON, MA 02466-1311

EIN/Tax ID: 042529800
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No