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Rapid breath detection of colorectal cancer with a colorimetric sensor array

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
Program Year/Program:
2012 / SBIR
Agency Tracking Number:
U43CA170238
Solicitation Year:
2012
Solicitation Topic Code:
NCI
Solicitation Number:
PAR10-286
Small Business Information
ISENSE, LLC
500 AUSTRALIAN AVE S, STE 120 WEST PALM BEACH, FL 33401-6223
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2012
Title: Rapid breath detection of colorectal cancer with a colorimetric sensor array
Agency: HHS
Contract: 1U43CA170238-01
Award Amount: $137,960.00
 

Abstract:

DESCRIPTION (provided by applicant): Project Summary/Abstract Recently it has been reported that canines can detect the presence of colon cancer from the scent of exhaled breath, with 91% selectivity and 99% specificity (Sonoda, H. et al., Gut, 2011, 60,814). The prospect of a device which can perform similarly opens the prospect of a rapid, non-invasive, accurate and inexpensive breath test for colon cancer. The iSense Medical Corp. (IMC) sensor operates analogously to biological olfaction in that a diverse array of cross- reactive chemical sensors is activated by the breath sample. Prior work has shown this sensor system, based on colorimetric indicators embedded in a nanoporous sol-gel matrix of very high surface area, to be capable of discrimination ofcomplex mixtures (Suslick, B. et al., Anal. Chem. 2010, 82, 2067), and has recently been shown in clinical testing at the Cleveland Clinic Foundation (CCF) to detect the presence of lung cancer from exhaled breath, across stages, with accuracy of 85% (Mazzone, P. et al., J. Thoracic Oncology, in press). Under this contract we propose to customize the nanoporous indicator array to optimize its sensitivity to small molecule metabolites of active colon tumor, and in Phase 2 conduct a pilot study at CCF to quantify accuracy of detection of colon cancer from breath, by stage. PUBLIC HEALTH RELEVANCE: Project Narrative The proposed research effort will develop a rapid, inexpensive and non-invasive diagnostic test for the presence of colon cancer, as a prompt for subsequent colonoscopic examination. A further application of this technology would be a breath test to non-invasively and inexpensively monitor the efficacy of chemotherapy treatment.

Principal Investigator:

Ray A. Martino
650-938-6200
prhodes@evolvedmachines.com

Business Contact:

Paul Rhodes
650-938-6200
prhodes@evolvedmachines.com
Small Business Information at Submission:

ISENSE, LLC
500 AUSTRALIAN AVE S, STE 120 WEST PALM BEACH, FL 33401-6223

EIN/Tax ID: 126042099
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No