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IGF::OT::IGF OTHER FUNCTIONS TOPIC 267, MULTIFUNCTIONAL THERAPEUTICS USING…

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
Program Year/Program:
2012 / SBIR
Agency Tracking Number:
N44CO120038
Solicitation Year:
2012
Solicitation Topic Code:
NCI
Solicitation Number:
Small Business Information
NanoVector, Inc.
PO BOX 98385 RALEIGH, NC 27624-8385
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 2012
Title: IGF::OT::IGF OTHER FUNCTIONS TOPIC 267, MULTIFUNCTIONAL THERAPEUTICS USING ENGINEERED PLANT VIRUS NANOPARTICLES
Agency: HHS
Contract: N44CO120038
Award Amount: $1,199,956.00
 

Abstract:

A biologic nanoparticle is the basis of this proposal. The plant virus nanoparticle (PVN) is based on a virus that: exists in the human food chain; is nontoxic and of low immunogenicity; can load medical imaging agents and/or therapeutic drugs into itscargo chamber by a simple process; and can be engineered to identify and enter cancer cells and release drug payloads inside cell structures, such as the nucleus where most anticancer drugs operate, bypassing most cancer cell defenses. It has a highly evolved sensor/actuator system to release cargo only in the targeted cell. In this Phase II project, NanoVector, Inc. will: perform mouse pharmacology studies and efficacy studies using human melanoma xenografts; increase PVN production efficiency and scalability; perform long term toxicity studies with biodistribution and bioelimination data, as well as early IND enabling studies, and initiation of large animal studies.

Principal Investigator:

Bruce Oberhardt
919-848-6520
BOBERHARDT@NANOVECTORINC.COM

Business Contact:

Bruce Oberhardt
919-848-6520
BOBERHARDT@NANOVECTORINC.COM
Small Business Information at Submission:

NANOVECTOR, INC.
PO BOX 98385 RALEIGH, NC 27624-8385

EIN/Tax ID: 999999999
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No