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IGF::OT::IGF OTHER FUNCTIONS TOPIC 267, MULTIFUNCTIONAL THERAPEUTICS USING ENGINEERED PLANT VIRUS NANOPARTICLES

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: N44CO120038
Agency Tracking Number: N44CO120038
Amount: $1,199,956.00
Phase: Phase II
Program: SBIR
Solicitation Topic Code: NCI
Solicitation Number: N/A
Timeline
Solicitation Year: 2012
Award Year: 2012
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
PO BOX 98385
RALEIGH, NC 27624-8385
United States
DUNS: 825302644
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 BRUCE OBERHARDT
 (919) 848-6520
 BOBERHARDT@NANOVECTORINC.COM
Business Contact
 BRUCE OBERHARDT
Phone: (919) 848-6520
Email: BOBERHARDT@NANOVECTORINC.COM
Research Institution
 Stub
Abstract

A biologic nanoparticle is the basis of this proposal. The plant virus nanoparticle (PVN) is based on a virus that: exists in the human food chain; is nontoxic and of low immunogenicity; can load medical imaging agents and/or therapeutic drugs into itscargo chamber by a simple process; and can be engineered to identify and enter cancer cells and release drug payloads inside cell structures, such as the nucleus where most anticancer drugs operate, bypassing most cancer cell defenses. It has a highly evolved sensor/actuator system to release cargo only in the targeted cell. In this Phase II project, NanoVector, Inc. will: perform mouse pharmacology studies and efficacy studies using human melanoma xenografts; increase PVN production efficiency and scalability; perform long term toxicity studies with biodistribution and bioelimination data, as well as early IND enabling studies, and initiation of large animal studies.

* Information listed above is at the time of submission. *

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