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IGF::OT::IGF OTHER FUNCTIONS SBIR PHASE II, TOPIC 288, RECOMBINANT ANTIBODIES…

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
Program Year/Program:
2012 / SBIR
Agency Tracking Number:
N44CO120094
Solicitation Year:
2012
Solicitation Topic Code:
NCI
Solicitation Number:
Small Business Information
AVANTGEN, INC.
AVANTGEN, INC. 10151 Pacific Mesa Blvd. SAN DIEGO, CA 92129-4571
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 2012
Title: IGF::OT::IGF OTHER FUNCTIONS SBIR PHASE II, TOPIC 288, RECOMBINANT ANTIBODIES AS AFFINITY CAPTURES
Agency: HHS
Contract: N44CO120094
Award Amount: $747,441.00
 

Abstract:

The objective of this proposed project is to develop recombinant antibodies against 75 cancer-related proteins. In the Phase I study, we have demonstrated that multiple antibody clones could be isolated from a large yeast displayed human antibody library.The isolated antibodies exhibit high affinity (lOW nM to sub-nM) and high specificity compariable to monoclonal antibodies derived from hybridoma technology. In parallel, the technology platform was optimzed to support more robust full length IgG display and consistent antibody expression in yeast cells. In this proposed Phase II project, we propose to isolate antibodies against 75 cancer related antigens developed by NCI's Clinical Proteomic Technologies Initiative using AvantGn's proprietary yeast display antibody library. The isolated antibodies will be characterized in terms of affinity (on and off binding constants) and specificity, and for performance in commonly used assays such as immunoprecipitation, and/or Western blot, with the goal of identifying 2 distinct antibody clones per antigen suitable for developing ELiSAs. These antibodies will be further intergrated into proteomic research platforms in collabration with NCI's Clinical Proteomic Technologies Initiative.

Principal Investigator:

Xiaomin Fan
858-768-8107
XFAN@AVANTGEN.COM

Business Contact:

Xiaomin Fan
858-768-8107
XFAN@AVANTGEN.COM
Small Business Information at Submission:

AVANTGEN, INC.
AVANTGEN, INC. SAN DIEGO, CA 92129-4571

EIN/Tax ID: 120215784
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No