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IGF::OT::IGF OTHER FUNCTIONS TOPIC 301, PHARMACO-KINESIS CORPORATION PHASE I…

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
Program Year/Program:
2012 / SBIR
Agency Tracking Number:
N43CO120036
Solicitation Year:
2012
Solicitation Topic Code:
NCI
Solicitation Number:
Small Business Information
PHARMACO-KINESIS CORPORATION
5933 W. Century Blvd Suite 1010 Los Angeles, CA 90304-1116
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2012
Title: IGF::OT::IGF OTHER FUNCTIONS TOPIC 301, PHARMACO-KINESIS CORPORATION PHASE I ENTITLED A VEGF NANOSENSOR TO MONITOR TUMOR PROGRESSION
Agency: HHS
Contract: N43CO120036
Award Amount: $170,009.00
 

Abstract:

The overarching goal of this project is to develop and commercialize a nanotechnology-based diagnostic platform capable of monitoring tumor microenvironments in vivo. Specifically, PKC will develop a biosensor based on carbon nanotube transistor technologies for monitoring levels of vascular endothelial growth factor (VEGF) proteins, a general biomarker associated with tumors. In the Phase I stage of the project (this contract research), PKC will first complete the design and fabrication of a prototypenanosensor and then evaluate its performance in detecting various clinically relevant VEGF levels in cerebral spinal fluid (CSF) in vitro. In the upcoming Phase II stage, the nanosensor will be integrated into PKC's Metronomic Biofeedback Pump (MBP) totest its long term performance in detecting VEGF in vivo. Overall, it is expected that the VEGF nanosensor will exploit the great sensitivity of carbon nanotubes to achieve detection of VEGF proteins at the clinically relevant range (10 ~ 10,000 pg/mL in CSF). Upon integration of the VEGF nanosensor into the MBP the levels of this biomarker will be monitored in vivo, in real-time, and for the entire length of the therapy (long term), making personalized medicine a reality. To reach the goals of this Phase I study, a detailed Statement-of-Work (SOW) and a list of major deliverables are provided below.

Principal Investigator:

Marco Curreli
310-734-4447
MARCOCURRELI@GMAIL.COM

Business Contact:

Marco Curreli
310-734-4447
MARCOCURRELI@GMAIL.COM
Small Business Information at Submission:

PHARMACO-KINESIS CORPORATION
5933 W. Century Blvd Suite 1010 Los Angeles, CA 90304-1116

EIN/Tax ID: 999999999
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No