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IGF::OT::IGF OTHER FUNCTIONS RandD- MEDICAL: BIOMEDICAL (APPLIED…

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
Program Year/Program:
2012 / SBIR
Agency Tracking Number:
N43CO120059
Solicitation Year:
2012
Solicitation Topic Code:
NCI
Solicitation Number:
Small Business Information
ENLYTON, LTD
7700 RIVERS EDGE DRIVE COLUMBUS, OH 43235-
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2012
Title: IGF::OT::IGF OTHER FUNCTIONS RandD- MEDICAL: BIOMEDICAL (APPLIED RESEARCH/EXPLORATORY DEVELOPMENT)
Agency: HHS
Contract: N43CO120059
Award Amount: $249,525.00
 

Abstract:

Surgical resection of malignant tumors is the single most effective therapy for cancer. Long-term patient outcomes are strongly determined by the extent to which the surgeon can completely remove all diseased tissues. Present cancer imaging and detectionmethods often fail to provide a clear picture of the extent of disease. SPECT (single photon emission computed tomography) is a sizeable market with a large installed base of scanners. SPECT has not adequately been supported for use in cancer imaging.Recent developments SPECT/CT fused imaging technology with attenuation correction alter this picture. Enlyton proposes to develop and test a series of tunable antibody targeting compounds for SPECT imaging of adenocarcinoma (e.g., colorectal, pancreatic, gastric, esophageal, lung) in cancer patients. It is an aim of this proposal to construct specific antibody targeting compositions that can rapidly accumulate in tumors while clearing from circulation quickly. It is a further aim to validate in vivo the efficacy of the preferred single chain antibody configuration, and optimize the time to SPECT/CT imaging. The modified tumor targeting agent will be labeled with an appropriate radioisotope (123I) to enable dosing and imaging within 24 hours usingexisting SPECT and SPECT/CT imaging platforms.

Principal Investigator:

Thomas Zupancic
614-888-9220
TZUPANCIC@YAHOO.COM

Business Contact:

Thomas Zupancic
614-888-9220
TZUPANCIC@YAHOO.COM
Small Business Information at Submission:

ENLYTON, LTD
7700 RIVERS EDGE DRIVE COLUMBUS, OH 43235-

EIN/Tax ID: 999999999
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No