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OTHER FUNCTIONS - RandD BIOMEDICAL (BASIC RESEARCH)

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
Program Year/Program:
2012 / SBIR
Agency Tracking Number:
N43CO120082
Solicitation Year:
2012
Solicitation Topic Code:
NCI
Solicitation Number:
Small Business Information
ZONEONE PHARMA, INC.
QB3, 1700 4TH STREET STE 214 SAN FRANCISCO, CA 94158-
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2012
Title: OTHER FUNCTIONS - RandD BIOMEDICAL (BASIC RESEARCH)
Agency: HHS
Contract: N43CO120082
Award Amount: $215,999.00
 

Abstract:

The Hsp90 inhibitor 17-DMAG will be encapsulated in a nano-sized liposome formulation that is long-circulating with controlled drug release properties in tumor tissue. Reformulation of 17-DMAG in a nanoliposome will increase the dose intensity of 17-DMAG in solid tumors while reducing the hepatic, gastrointestinal, nausea and bone marrow toxicity. The key is devising a nanoliposome composition that will retain the drug in circulation and release the drug from the nanoliposome at an appropriate rate after accumulation in the tumor. ZoneOne Pharma will use a new class of sterol-modified lipids (SML) that enable a wide and predictable range of drug release rates from the nanoliposome to encapsulate 17-DMAG using a remote loading protocol. In this development plan, ZoneOne Pharma will design nanoliposome compositions of 17-DMAG for evaluation by loading efficiency, in vitro plasma stability, in vivo pharmacokinetic and biodistribution studies. These formulations will be evaluated for tumor release effect on therapeutic activity in a proof-of-concept efficacy study at the end of Phase 1. A single formulation will be selected from confirmation efficacy studies as the first step of a future Phase II project.

Principal Investigator:

Charles Noble
415-476-9792
CNOBLE@ZONEONEPHARMA.COM

Business Contact:

Charles Noble
415-476-9792
CNOBLE@ZONEONEPHARMA.COM
Small Business Information at Submission:

ZONEONE PHARMA, INC.
QB3, 1700 4TH STREET STE 214 SAN FRANCISCO, CA 94158-

EIN/Tax ID: 999999999
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No