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OTHER FUNCTIONS-ANTIBODY PROTEOMICS FOR MEASURING LIPOPROTEIN SUB-POPULATIONS

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
Program Year/Program:
2012 / SBIR
Agency Tracking Number:
N43HL120064
Solicitation Year:
2012
Solicitation Topic Code:
NHLBI
Solicitation Number:
N/A
Small Business Information
HDL APOMICS LLC
560 MAIN ST ALLENHURST, NJ 07711-1232
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2012
Title: OTHER FUNCTIONS-ANTIBODY PROTEOMICS FOR MEASURING LIPOPROTEIN SUB-POPULATIONS
Agency: HHS
Contract: N43HL120064
Award Amount: $139,291.00
 

Abstract:

Cardiovascular disease is a leading cause of morbidity and mortality and both high LDL-C and low HDL-C remain validated factors that predict and contribute to risk. Reliance on the lipid, cholesterol, as the surrogate marker to measure total LDL and HDL has limitations and provides inadequate understanding. Lipoproteins are heterogeneous populations of particles whose physiochemical properties are dictated by the sum of their lipid and protein constituents. A fact infers that for particles capable of physical separation, a difference in their lipidomic and proteomic content must exist. Given that each lipoprotein particle contains a limited set of associating proteome members, analytical methodologies can take advantage of those proteins with restricted particle population distributions. Utilizing these proteins as markers for selective particle sub populations provide a means for quantify them. The novel technology offered in this proposal uses the diversity of the lipoprotein proteome to identify and measure sub-populations directly from a plasma sample. This approach measures multiple proteome members simultaneously in a multiplex assay format and generates a lipoprotein fingerprint . These snapshots can be used to assess cardiovascular health by monitoring lipoprotein population dynamics and characterize the differences resulting from genetic disposition, disease and therapeutic intervention.

Principal Investigator:

Scott Altmann
SCOTT.ALTMANN@HDL-APOMICS.COM

Business Contact:

Scott Altmann
SCOTT.ALTMANN@HDL-APOMICS.COM
Small Business Information at Submission:

HDL APOMICS LLC
560 MAIN ST ALLENHURST, NJ 99999-

EIN/Tax ID: 999999999
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No