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SBIR Phase I: Innovative Tripolar Concentric Ring Electrode…

Award Information

Agency:
National Science Foundation
Branch:
N/A
Award ID:
Program Year/Program:
2013 / SBIR
Agency Tracking Number:
1248654
Solicitation Year:
2012
Solicitation Topic Code:
BC
Solicitation Number:
Small Business Information
CREmedical Corporation
110 Bean Farm Drive Kingston, RI 02881-1223
View profile »
Woman-Owned: No
Minority-Owned: Yes
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2013
Title: SBIR Phase I: Innovative Tripolar Concentric Ring Electrode Electroencephalography (tEEG) to Advance Epilepsy Diagnosis
Agency: NSF
Contract: 1248654
Award Amount: $149,915.00
 

Abstract:

This Small Business Innovation Research Phase I project aims to establish the feasibility of innovative tripolar concentric ring electrode electroencephalography (tEEG) for epilepsy diagnosis. Epilepsy is the most common serious brain disorder worldwide. Presently, EEG is the primary diagnostic tool for epilepsy, but misdiagnosis occurs in up to 50% of the patients. The root cause of misdiagnosis lies in the poor signal fidelity of EEG which stems in part from signal contamination with noise. The proposed tEEG technology achieves superior signal fidelity through two inventions: (1) the tripolar concentric ring electrode (TCRE), a transformative electrode configuration which overcomes the limitations of the conventional electrode; and (2) a proprietary interface circuit which serves as a preamplifier to conventional EEG amplifiers. This project will accomplish two specific aims. The first aim is to improve the design of the clinical tEEG prototype. The second aim is to evaluate tEEG against conventional EEG in adult and pediatric patients with epilepsy. Success will be determined by expert review and quantitative analysis. tEEG is expected to exhibit higher interpretability and quantitative performance than conventional EEG, helping improve epilepsy diagnosis. The broader impact/commercial potential of this project is three-fold: (1) Commercial Value. tEEG is a platform technology that has a variety of medical and commercial applications. By providing significantly higher fidelity which leads to improved signal interpretability, tEEG will resolve conventional EEG?s major drawback and a fundamental problem that clinicians and researchers have been struggling with for decades. tEEG can advance diagnosis and fill unmet clinical and research needs. Commercially, tEEG can transform the market landscape and set a new standard for EEG equipment. (2) Societal Impact. The fundamental improvement promised by tEEG and its non-invasive nature are particularly appealing. tEEG has the potential to greatly simplify and advance the diagnosis of a wide spectrum of neurological disorders and more effectively guide neurosurgical and other medical procedures. (3) Enhanced Scientific and Technological Understanding. tEEG can benefit a host of brain and behavioral research areas. The fundamental improvement in signal fidelity and artifacts rejection will help advance the understanding of brain activity, leading to new discoveries in the research of various brain diseases and neurological disorders. The increased signal fidelity from tEEG may advance research of biomarkers to quantify neurological disorders with tEEG which was not previously possible.

Principal Investigator:

Walter G. Besio
4012842431
a_besio@yahoo.com

Business Contact:

Walter G. Besio
4012842431
a_besio@yahoo.com
Small Business Information at Submission:

CREmedical Corporation
110 Bean Farm Drive Kingston, RI 02881-1223

EIN/Tax ID: 453459610
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: Yes
HUBZone-Owned: No