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Nano-Therapeutics for Peripheral Neuropathy

Award Information

Department of Defense
Award ID:
Program Year/Program:
2013 / SBIR
Agency Tracking Number:
Solicitation Year:
Solicitation Topic Code:
Solicitation Number:
Small Business Information
Physical Optics Corporation
Electro-Optics Systems Division 1845 West 205th Street Torrance, CA 90501-1510
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Woman-Owned: Yes
Minority-Owned: No
HUBZone-Owned: No
Phase 1
Fiscal Year: 2013
Title: Nano-Therapeutics for Peripheral Neuropathy
Agency: DOD
Contract: W81XWH-13-C-0014
Award Amount: $149,927.00


To address the DHP need for a controlled, target-specific delivery system for topical treatment of peripheral neuropathy (PN), Physical Optics Corporation (POC) proposes to develop Nano Therapeutics for Peripheral Neuropathy (NATPEN). The NATPEN will include a nanocarrier (NC) loaded with specific drugs, a biocompatible gel to contain the NC, and a microneedle patch for transdermal delivery of the therapeutic. The innovations in the NATPEN as a topical treatment modality will enable minimally invasive, extended, targeted delivery of drugs to the peripheral terminals of the sensory neurons. The NATPEN modality has minimal toxicity and is easy to administer. In Phase I, POC will demonstrate the feasibility of the NATPEN concept by developing a prototype of a topical drug delivery system capable of transporting the therapeutic through skin and having nerve targeting capability and controlled release of the drug. In Phase II, POC plans to optimize, demonstrate, and validate the therapeutic modality in animal models of PN. The FDA approval pathway will be outlined and considered at each developmental stage.

Principal Investigator:

Gregory Zeltser
Principal Scientist
(310) 320-3088

Business Contact:

Gordon Drew
Chief Financial Officer
(310) 320-3088
Small Business Information at Submission:

Physical Optics Corporation
Photonic Systems Division 1845 W. 205th Street Torrance, CA -

EIN/Tax ID: 330118051
Number of Employees:
Woman-Owned: Yes
Minority-Owned: No
HUBZone-Owned: No