USA flag logo/image

An Official Website of the United States Government

Epicutaneous Gel for Delivery of Targeted Therapeutic to Treat Peripheral…

Award Information

Agency:
Department of Defense
Branch:
N/A
Award ID:
Program Year/Program:
2013 / SBIR
Agency Tracking Number:
H122-013-0238
Solicitation Year:
2012
Solicitation Topic Code:
DHP12-013
Solicitation Number:
2012.2
Small Business Information
Lynntech, Inc.
2501 Earl Rudder Freeway South College Station, TX 77845-
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2013
Title: Epicutaneous Gel for Delivery of Targeted Therapeutic to Treat Peripheral Neuropathy
Agency: DOD
Contract: W81XWH-13-C-0039
Award Amount: $150,000.00
 

Abstract:

Peripheral Neuropathy (PN) is a painful debilitating condition caused by progressive subcutaneous nerve damage due to diabetes, chemotherapy or as a result of traumatic combat injuries. Systemic or topical administration of existing therapeutics alleviates pain but does not address progressive nerve damage. High dosages requisite for therapeutic effect increase long-term toxicity risk. Lynntech, Inc. proposes a biocompatible epicutaneous gel system to (a) topically deliver a therapeutic which may mitigate pain and halt or reverse nerve damage, (b) directly target receptors on neurons to reduce dosage and decrease long term toxicity risk and (c) be easily administered due to its familiar topical gel format. Phase I will provide proof-of-concept for improved neuronal targeted delivery of the therapeutic as directly compared to delivery of a currently utilized NSAID using an appropriate in vitro 3D skin equivalent model. Phase II will further optimize the topical gel system and therapeutic for improved skin barrier penetration and increased neuronal targeting ability which will be demonstrated using an appropriate in vivo model of PN. This innovative epicutaneous gel system is of direct relevance to the missions and goals of the USAMRMC as it may significantly improve the quality of life of our soldiers with PN.

Principal Investigator:

Anjal Sharma
Scientist II
(979) 764-2200
anjal.sharma@lynntech.com

Business Contact:

G. R. Hisaw
Sr. Contracts Administrator
(979) 764-2218
renee.hisaw@lynntech.com
Small Business Information at Submission:

Lynntech, Inc.
2501 Earl Rudder Freeway South College Station, TX -

EIN/Tax ID: 742463014
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No