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STTR Phase II: Constitutive Promoters for Crop Improvement

Award Information

Agency:
National Science Foundation
Branch:
N/A
Award ID:
88533
Program Year/Program:
2010 / STTR
Agency Tracking Number:
0810649
Solicitation Year:
N/A
Solicitation Topic Code:
BE1
Solicitation Number:
N/A
Small Business Information
GRASSROOTS BIOTECHNOLOGY, INC.
302 E PETTIGREW ST STE A200 Durham, NC 27701-3712
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: Yes
 
Phase 2
Fiscal Year: 2010
Title: STTR Phase II: Constitutive Promoters for Crop Improvement
Agency: NSF
Contract: 0957836
Award Amount: $500,000.00
 

Abstract:

This Small Business Technology Transfer (STTR) Phase II project seeks to identify new and improved promoters to create enhanced genetically modified crops. Plant biotechnology relies on the insertion of promoter-gene constructs into plants. The promoter is the portion of DNA that controls when and where a gene is expressed. The relatively few plant promoters in use today have significant limitations including inconsistent effects across different growing conditions and a lack of predictability. This project involves developing and implementing a novel pipeline for promoter discovery that starts with a sophisticated bioinformatics analysis to identify high confidence promoter candidates. Using fluorescent reporters and confocal imaging, these candidates are assessed in transgenic plants for cell-type-specific expression, developmental-stage-specific expression, and responsiveness to environmental stimuli. This pipeline was validated in the Phase I component of the project where four novel and patentable constitutive promoters were identified. The broader impacts of this research are the development of superior genetically modified crops. Genetically modified plants already play an important role in world agricultural production and will play a central role in averting widespread food shortages in the future. In addition, substantial research is being conducted to improve bioenergy crops though genetic engineering. Genetically enhanced bioenergy crops are predicted to play a key role in reducing our dependence on fossil fuels and in cutting greenhouse gas emissions. A critical innovation that will facilitate advances in all of these areas will be the introduction of new and enhanced plant promoters.

Principal Investigator:

Tedd D. Elich
9197477406
tedd.elich@grassrootsbio.com

Business Contact:

Tedd D. Elich
9197477406
tedd.elich@grassrootsbio.com
Small Business Information at Submission:

GrassRoots Biotechnology
302 East Pettigrew St. Suite 200-A Durham, NC 27701

EIN/Tax ID: 260691674
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Research Institution Information:
University of California-Davis
Davis One Shields Avenue Davis
Davis, CA 95616
Contact: Tedd Elich
Contact Phone: 9195368621