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Prevention of Bacterial Biofilms on CSF Shunts through the Incorporation of…

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
96486
Program Year/Program:
2010 / SBIR
Agency Tracking Number:
NS071776
Solicitation Year:
N/A
Solicitation Topic Code:
NINDS
Solicitation Number:
N/A
Small Business Information
AGILE SCIENCES, INC.
1791 Varsity Dr. RALEIGH, NC -
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2010
Title: Prevention of Bacterial Biofilms on CSF Shunts through the Incorporation of Novel
Agency: HHS
Contract: 1R43NS071776-01
Award Amount: $570,115.00
 

Abstract:

DESCRIPTION (provided by applicant): This NIH SBIR project assesses the feasibility of applying a discovery made by the cofounders of Agile Sciences, Inc. to developing a more effective therapeutic strategy toward preventing bacterial infections associated with CSF shunts. Bacterial infections associated with shunts are particularly difficult to treat as bacteria typically form a biofilm on the surface of the shunt. These biofilms act to protect the bacteria from antimicrobial intervention. The cofounders of Agile Sciences, Inc. have discovered a class of novel small molecules that inhibits bacteria9s ability to form biofilms as well as disperses pre-formed bacterial biofilms. The goal of this proposal is to incorporate Agile9s most potent and broadly actin g compound, named Agilyte , into CSF shunt catheters and to assess the antibiofilm and antimicrobial properties of these catheters using in vitro models. To this end, the Specific Aims of this Phase I SBIR Project are: 1. to incorporate Agilyte into silic one catheters. 2. To assess biofilm buildup of Staphylococcus aureus, Staphylococcus epidermidis and Pseudomonas aeruginosa on an Agilyte + antibiotic impregnated (AAI) silicone catheter using an in vitro model. 3. To assess the enhanced anti - biofilm an d antimicrobial properties of an Agilyte + antibiotic-impregnated (AAI) silicone catheter toward a clinical sample of bacteria in vitro. PUBLIC HEALTH RELEVANCE: Infections of cerebrospinal fluid (CSF) shunts occur in approximately 10% of all pati ents, and are associated with increased morbidity and mortality. A new strategy for reducing or eliminating these infections would result in substantial increase in quality of life for the hundreds of thousands of people living with hydrocephalus in the Un ited States.

Principal Investigator:

Stephen R. Brand

Business Contact:

Eva Garland
info@agilesci.com
Small Business Information at Submission:

AGILE SCIENCES, INC.
AGILE SCIENCES, INC. 3309 MILTON RD RALEIGH, NC -

EIN/Tax ID: 120875545
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No