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MULTIFUNCTIONAL SIRNA NANOPARTICLES FOR AML THERAPY

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
96066
Program Year/Program:
2010 / SBIR
Agency Tracking Number:
N43CO201000051
Solicitation Year:
N/A
Solicitation Topic Code:
NCI
Solicitation Number:
N/A
Small Business Information
Nanomaterial Innovation Ltd.
1109 Millcreek Lane Columbus, OH 43220-4949
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Woman-Owned: Yes
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2010
Title: MULTIFUNCTIONAL SIRNA NANOPARTICLES FOR AML THERAPY
Agency: HHS
Contract: N43CO201000051
Award Amount: $200,000.00
 

Abstract:

'This project will investigate transferrin (Tf) conjugated fluorescent nanoparticles loaded with an siRNA, LOR-1284, as a theranostic agent for acute myelogenous leukemia (AML). LOR-1284, a siRNA targeting the R2 subunit of ribonucleotide reductase (RNR), is a promising agent for overcoming RNR-mediated drug resistance in AML. The nanoparticles are designed to facilitate LOR-1284 delivery to AML cells (for therapy) while enabling easy detection of delivery efficiency to the AML cells in leukemia patients (for diagnosis). A novel microfluidic method has been developed for nanoparticle synthesis. This project will be carried out by a multidisciplinary team of investigators at NIL and at The Ohio State University.

Principal Investigator:

Xiaojuan Yang
Small Business Information at Submission:

NANOMATERIAL INNOVATION, LTD
1109 MILLCREEK LN COLUMBUS, OH 43220-4949

EIN/Tax ID: 201611183
DUNS: N/A
Number of Employees: N/A
Woman-Owned: Yes
Minority-Owned: No
HUBZone-Owned: No