MULTIFUNCTIONAL SIRNA NANOPARTICLES FOR AML THERAPY
'This project will investigate transferrin (Tf) conjugated fluorescent nanoparticles loaded with an siRNA, LOR-1284, as a theranostic agent for acute myelogenous leukemia (AML). LOR-1284, a siRNA targeting the R2 subunit of ribonucleotide reductase (RNR), is a promising agent for overcoming RNR-mediated drug resistance in AML. The nanoparticles are designed to facilitate LOR-1284 delivery to AML cells (for therapy) while enabling easy detection of delivery efficiency to the AML cells in leukemia patients (for diagnosis). A novel microfluidic method has been developed for nanoparticle synthesis. This project will be carried out by a multidisciplinary team of investigators at NIL and at The Ohio State University.
Small Business Information at Submission:
Principal Investigator:Xiaojuan Yang
NANOMATERIAL INNOVATION, LTD
1109 MILLCREEK LN COLUMBUS, OH 43220-4949
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