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Droplet-Based Automation of Complex Workflows for Synthetic Biology

Award Information

Department of Defense
Defense Advanced Research Projects Agency
Award ID:
Program Year/Program:
2013 / STTR
Agency Tracking Number:
Solicitation Year:
Solicitation Topic Code:
Solicitation Number:
Small Business Information
615 Davis Dr., Suite 800 PO Box 14025 RESEARCH TRIANGLE PARK, NC -
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Phase 1
Fiscal Year: 2013
Title: Droplet-Based Automation of Complex Workflows for Synthetic Biology
Agency / Branch: DOD / DARPA
Contract: D13PC00034
Award Amount: $99,713.00


Large-scale genome engineering represents a broad group of technologies, all of which stand to impact the manufacturing of a range of biological and chemical products. While the power of these methods to increase the production of biologically-driven manufacturing processes has been previously demonstrated, they are often developed and optimized toward a single target, or single methodology. Currently, an automation platform does not exist that enables a broad range of genome engineering methods directed towards a diverse range of biomanufactured products. Advanced Liquid Logic (ALL) has developed digital microfluidics, a highly flexible, software programmable liquid handling technology. ALL has demonstrated that this technology is capable of automating a range of bioassay workflows using relatively straightforward device designs and fabrication methods. During this program leaders in genome engineering will be engaged to help identify requirements; technology gaps and potential solutions to enable greater flexibility and capability will be evaluated; and system performance will be analyzed and benchmarked to other methods. The goal of this proposal is to lay the groundwork for the development, in Phase II, of a highly-flexible and less constrained digital microfluidic device, potentially using more advanced fabrication methods, for synthetic biology applications.

Principal Investigator:

Brent Lutz
President and CEO
(919) 287-9010

Business Contact:

Richard West
(919) 287-9010
Small Business Information at Submission:

Advanced Liquid Logic Inc.
615 Davis Drive, Suite 800 Research Triangle Pa, NC -

EIN/Tax ID: 201708967
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Research Institution Information:
Stanford University
340 Panama Street
Stanford, CA 94305-
Contact: Mark Horowitz
Contact Phone: (650) 725-3707