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A Nano-pharmaceutical Platform for Creating Artificial Vaccines

Award Information

Agency:
Department of Defense
Branch:
N/A
Award ID:
Program Year/Program:
2013 / SBIR
Agency Tracking Number:
O2-1303
Solicitation Year:
2011
Solicitation Topic Code:
OSD11-H01
Solicitation Number:
2011.1
Small Business Information
Parabon NanoLabs, Inc.
11260 Roger Bacon Drive Suite 406 Reston, VA -
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 2013
Title: A Nano-pharmaceutical Platform for Creating Artificial Vaccines
Agency: DOD
Contract: W911NF-13-C-0044
Award Amount: $749,918.00
 

Abstract:

In this project, Parabon NanoLabs will employ its Essemblix(tm) Drug Development Platform, a combination of computer-aided design (CAD) software and DNA nano-fabrication technology, to produce artificial vaccines against the biothreat agent ricin on DNA origami decorated first with natural epitopes and ultimately with artificial epitotopes (hereafter"mimotope") constructed from a predefined set of"building block molecules."Although this project focuses on a single biothreat agent, the ultimate goal is to advance the Essemblix technology such that, given an epitope for a potential biothreat agent, Essemblix will allow the production of mimotopes that can mimic the original epitope sufficiently to bind target antibodies with high affinity. In Phase I, we demonstrated Essemblix enables building block molecules to be arranged on origami in complex presentation patterns of the variety known to elicit rapid and potent immune response via T cell-independent activation and these techniques will be applied in Phase II. The resultant artificial vaccines, produced with natural and artificial epitopes, will be evaluated in murine studies to test their immunogenecity and toxicity, and a lead compound will be selected for further study, culminating in a demonstration of potency with lethal ricin challenge in mouse.

Principal Investigator:

Steven Armentrout
CEO
(703) 689-9689
steve@parabon.com

Business Contact:

Paula Gawthorp-Armentrout
Corporate Officer
(703) 689-9689
parmentrout@parabon.com
Small Business Information at Submission:

Parabon NanoLabs, Inc.
11260 Roger Bacon Drive Suite 406 Reston, VA -

EIN/Tax ID: 262194625
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No