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Improved Dried Biological Specimen Materials, Recovery and Processing for…

Award Information

Agency:
Department of Defense
Branch:
Defense Advanced Research Projects Agency
Award ID:
Program Year/Program:
2013 / SBIR
Agency Tracking Number:
D2-1159
Solicitation Year:
2011
Solicitation Topic Code:
SB112-005
Solicitation Number:
2011.2
Small Business Information
Connecticut Analytical Corporation
696 Amity Road Route 63 Bethany, CT -
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 2013
Title: Improved Dried Biological Specimen Materials, Recovery and Processing for Diagnostics
Agency / Branch: DOD / DARPA
Contract: W31P4Q-13-C-0073
Award Amount: $998,795.00
 

Abstract:

The dried blood spot (DBS) method is an alternative to venipuncture. The available data indicates that the DBS method is both precise and accurate for a diverse range of compounds. We discovered that proprietary additives vastly improve extraction of proteins in DBS using electrospray. Our unexpected results appear to dramatically increase analyte recovery concentration while reducing DBS prep, and may have a significant impact on ESI-MS methodology. We are proposing to apply and validate the extraction process over a comprehensive range of clinical panels, validate the test methods for clinical relevance with independent labs, investigate the role of our proprietary additives, and optimize the extraction method with several Universities. Our primary goal is to deliver a final system suitable for implementation into DARPA's ADEPT program. In a possible Phase II Option, we will continue development seeking FDA approval using a CLIA waived approach together with Yale New Haven Hospital's Clinical labs, which will assist in the clinical trials. The proposed program will have the following benefits: a dried analyte capture, storage, and recovery method that can be used by minimally trained individuals that yields CLIA waived clinically accepted tests for analyte panels now routinely reserved for whole blood or serum.

Principal Investigator:

Joseph J. Bango
Principal Investigator
(203) 393-9666
jbango@ctanalytical.com

Business Contact:

Joseph Bango
President
(203) 393-9666
jbango@ctanalytical.com
Small Business Information at Submission:

Connecticut Analytical Corporation
696 Amity Road Route 63 Bethany, CT -

EIN/Tax ID: 061279411
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No