USA flag logo/image

An Official Website of the United States Government

Vaccine Adjuvant for Rapid Tolerance Induction in Allergy Patients

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
Program Year/Program:
2013 / SBIR
Agency Tracking Number:
R43AI104178
Solicitation Year:
2013
Solicitation Topic Code:
NIAID
Solicitation Number:
PA10-123
Small Business Information
TRIA BIOSCIENCE CORPORATION
1616 EASTLAKE AVE E STE 260 SEATTLE, WA -
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2013
Title: Vaccine Adjuvant for Rapid Tolerance Induction in Allergy Patients
Agency: HHS
Contract: 1R43AI104178-01
Award Amount: $579,383.00
 

Abstract:

DESCRIPTION (provided by applicant): Allergy is a major cause of illness and disability with an estimated 40-50 million people afflicted in the US alone. AIT provides long-term benefits for the patient and its need for optimization creates a compelling business opportunity. There is a very strong rationale to develop GLA for allergy based on its superior drug profile to MPL, a related TLR4 agonist that accelerates desensitization in people. Our preclinical development plan is easy to execute given the vaccines simple design, and it is very low risk given GLA's safety record in toxicology studies and current clinical programs. This Phase I SBIR will clarify the pharmacology and product profile for the IND. The goal is to confirm that GLA will augment the immunogenicity of multiple allergens and verify that it can accelerate desensitization in a compelling manner. The intention is to generate three potential vaccine candidates for evaluation by an external advisory board. In addition to new innovative allergy products, this work will help us understand the mechanisms of IgE-mediated disease and how to effectively cure allergy through tolerance induction. TRIA has the resources and experience to complete the task. PUBLIC HEALTH RELEVANCE PUBLIC HEALTH RELEVANCE: Allergy is a major cause of illness and disability with an estimated 40-50 million people afflicted in the US alone. Allergy immunotherapy cures some patients although it is underutilized and suffers from poor compliance. Adjuvants can be mixed with allergy vaccines to accelerate tolerance with fewer injections and no adverse reactions.

Principal Investigator:

Christopher H. Clegg
206-819-9413
cclegg@triabio.com

Business Contact:

Marcia Tapp
206-826-7954
mtapp@triabio.com
Small Business Information at Submission:

TRIA BIOSCIENCE CORPORATION
1616 EASTLAKE AVE E STE 260 SEATTLE, WA -

EIN/Tax ID: 127028759
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No