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Minimal Residual Disease Monitoring by T-cell Receptor Repertoire Profiling

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
Program Year/Program:
2013 / SBIR
Agency Tracking Number:
R43CA167972
Solicitation Year:
2013
Solicitation Topic Code:
NCI
Solicitation Number:
PA12-088
Small Business Information
ADAPTIVE TCR CORPORATION
1551 Eastlake Avenue East Suite 200 SEATTLE, WA 98102-
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2013
Title: Minimal Residual Disease Monitoring by T-cell Receptor Repertoire Profiling
Agency: HHS
Contract: 1R43CA167972-01A1
Award Amount: $165,191.00
 

Abstract:

DESCRIPTION (provided by applicant): Minimal Residual Disease Monitoring by T-cell Receptor Repertoire Profiling T-cell neoplasms are generally more aggressive and have poorer outcomes than comparable B-cell lymphomas. In addition, for many of these patients, prognosis following disease relapse is dismal. Detecting the presence or absence of Minimal Residual Disease (MRD) following treatment is emerging as an alternative method to stratify relapse risk and individualize patient treatment. Depending on the type of T cell malignancy, a number of methods are clinically used to detect MRD. However, these assays can only reliably detect MRD in the range of 1:100 to 1:10,000 cells, thus detection is only possible once malignant cells have reached an appreciable frequency, past the point where treatment could be most effective. Herein, we propose a new method for identifying neoplastic lymphoid populations and measuring MRD by direct sequencing of the T-cell receptor (TCR) repertoire using our established high-throughput T-cell receptor sequencing technology. Our semi-quantitative technology is sensitive and can detect clones down to fewer than 1:100,000 cells (10-fold increased sensitivity over standard methods). This method will be further developed and validatedfor potential clinical applications through a collaborative project using samples from a cohort of mature T-cell lymphoma patients. The findings from this study will not only be relevant for assessment of MRD in T-cell neoplasms; its extension to the detection of MRD in B-cell neoplasms will expand the applicability of this assay to all hematological neoplasms. PUBLIC HEALTH RELEVANCE PUBLIC HEALTH RELEVANCE: Minimal Residual Disease Monitoring by T-cell Receptor Repertoire Profiling The goal ofthis phase I SBIR submission is to evaluate the sensitivity and utility of high- throughput sequencing of T-Cell Receptor (TCR) loci to monitor minimal residual disease (MRD) in patients who have undergone treatment for mature T cell lymphomas. The findings from this study will not only result in a more sensitive assay of MRD in T-cell neoplasms; its extension to the detection of MRD in B-cell neoplasms will expand the applicability of this asay to al hematological neoplasms.

Principal Investigator:

Mark J. Rieder
206-659-0067
mrieder@adaptivebiotech.com

Business Contact:

Caterina Bertucci
206-436-6357
cbertucci@adaptivebiotech.com
Small Business Information at Submission:

ADAPTIVE TCR CORPORATION
1551 Eastlake Avenue East Suite 200 SEATTLE, WA 98102-

EIN/Tax ID: 127090702
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No