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Improving Pediatric Developmental Screening and Communication: A CME

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
Program Year/Program:
2013 / SBIR
Agency Tracking Number:
R43DA036242
Solicitation Year:
2013
Solicitation Topic Code:
NIDA
Solicitation Number:
PA12-088
Small Business Information
ALLELE BIOTECHNOLOGY AND PHARMACEUTICALS
9924 Mesa Rim Road SAN DIEGO, CA 92121-2910
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Woman-Owned: No
Minority-Owned: Yes
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2013
Title: Improving Pediatric Developmental Screening and Communication: A CME
Agency: HHS
Contract: 1R43DA036242-01
Award Amount: $199,939.00
 

Abstract:

DESCRIPTION (provided by applicant): The goal of the proposed project is to develop a commercial kit that will allow drug addiction researchers with ongoing projects using cell-based models to be able to successfully and conveniently produce human inducedpluripotent stem cells (iPSCs). Addiction to drugs destroys lives of substance abusers and their families, creating enormous social problems and exerting cost on the nation's health care system. Molecular mechanisms that contribute to the initiation and establishment of addiction are largely unknown, partially due to the lack of neural cell types from the patients. The technologies that made possible of human iPSCs opened the doors to new areas of direct interrogation of the pathophysiology of addiction byusing patient-specific cell sources. Currently, the NIDA is funding projects that rely on iPS technologies to: 1) characterize dopaminergic neurotransmission function of neurons derived from iPSCs with genomic aberrations, such as chromosomal polymorphismregions containing dopamine transporter (DAT) and vesicular monoamine transporter (VMAT2) genes; 2) identify genetic variations that can be functionally correlated to addiction in patient cell-derived neurons via iPSCs; 3) make dopamine neurons from patient iPSCs and expose them to methamphetamine and withdrawal in order to analyze the electrophysiological properties of patient-specific neurons versus controls, etc. Even though it is considered a technology with great potential in studies of addiction or other diseases, reprogramming of adult human cells to iPSCs is still an inefficient, tedious and costly process to most researchers. The currently prevailing methods of reprogramming have additional problems such as alteration of genomes or introduction of viruses that can complicate the interpretation of results from the cell-based assays. This project aims to develop a turn-key tool kit that will enable many biomedical researchers to generate iPSCs not only with 10 to 100 folds higher efficiency than othermethods, in less than 2 weeks, but also through a feeder-free, xeno-free and footprint-free procedure. PUBLIC HEALTH RELEVANCE PUBLIC HEALTH RELEVANCE: The goal of the proposed research is to develop a research tool kit for highly efficient generation of human induced pluripotent stem cells from adult cells. The technology will allow discoveries of novel therapies using stem cells or patient-specific disease models.

Principal Investigator:

Jiwu Wang
858-587-6645
jiwuwang@allelebiotech.com

Business Contact:

Jiwu Wang
858-587-6645
jiwuwang@allelebiotech.com
Small Business Information at Submission:

ALLELE BIOTECHNOLOGY AND PHARMACEUTICALS
9924 Mesa Rim Road SAN DIEGO, CA 92121-2910

EIN/Tax ID: 152220107
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: Yes
HUBZone-Owned: No