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A Theranostic Tool to Assess and Enable Spared Spinal Motor Function After SCI

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R43DA037586-01
Agency Tracking Number: R43DA037586
Amount: $217,053.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: NIDA
Solicitation Number: PA13-088
Timeline
Solicitation Year: 2013
Award Year: 2013
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
5611 ROOSEVELT ST
BETHESDA, MD -
United States
DUNS: 809594661
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 ROLAND PROBST
 (301) 346-7944
 rolandWMP@gmail.com
Business Contact
 IRVING MD
Phone: (301) 346-7944
Email: inweinberg@gmail.com
Research Institution
 Stub
Abstract

DESCRIPTION (provided by applicant): The ultimate goal of this project is to develop instrumentation for high resolution screening and sorting of small live invertebrates, for use in basic biological research and drug discovery. The instrument (developed by the PI, who is a New Investigator) will be capable of rapid, robust, and accurate sorting based on the user's choice of either morphological or fluorescent labels (or of a combination of both methods). The proposed system features high animal viability (by applying feedback control that minimizes applied forces during immobilization) and rapid animal processing (by automating image-guided sorting and analysis procedures). Successful completion of the Phase I aims will provide us with information that canbe demonstrated to potential customers and strategic partners (who have already expressed an interest in the product), and prepare us for Phase II scientific studies of that will exploit the sub-cellular characterization capability of the system to examineimportant hematological constructs. The device will fit on microscopes already available in biology laboratories, reducing overall cost and laboratory footprint. Initial marketing studies suggest a potential installed base of 2,500 biology labs worldwide.Competitive approaches require integration of image analysis and robotic sorting systems from multiple vendors, costing well over 300,000. With a projected system price of 50,000 per integrated image analysis/sorting system and an already-identified strategic partner, we expect rapid penetration into this community. PUBLIC HEALTH RELEVANCE PUBLIC HEALTH RELEVANCE: The ultimate goal of this project is to develop instrumentation for high resolution screening and sorting of small live invertebrates, for use in basic biological research and drug discovery.

* Information listed above is at the time of submission. *

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