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Novel Design of a Fast-On/Fast-Off Insulin Analog for Closed-Loop Systems

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
Program Year/Program:
2013 / SBIR
Agency Tracking Number:
R43GM108261
Solicitation Year:
2013
Solicitation Topic Code:
NIGMS
Solicitation Number:
PA12-088
Small Business Information
MASSTECH, INC.
6992 COLUMBIA GATEWAY DR, #200 COLUMBIA, MD 21046-2985
View profile »
Woman-Owned: No
Minority-Owned: Yes
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2013
Title: Novel Design of a Fast-On/Fast-Off Insulin Analog for Closed-Loop Systems
Agency: HHS
Contract: 1R43GM108261-01
Award Amount: $150,000.00
 

Abstract:

DESCRIPTION: Significant increase in the efficiency and speed of MS-based tissue imaging (IMS) performed at atmospheric conditions using high-resolution mass spectrometer will have a profound impact on method applications to the entire analytical field ofcharacterization of biomarkers in tissues. At present, the efficiency of the MS-based tissue imaging is limited by low sensitivity. We propose to employ a separate post-ionization step to increase the ion yield from the material ablated by laser from thetissues. To demonstrate high-throughput IMS analysis based on the proposed post-ionization technique, we plan to modify the house-built compact UV laser system capable of generation high-intensity laser pulses at very high repetition rate. PUBLICHEALTH RELEVANCE PUBLIC HEALTH RELEVANCE: Mass spectrometry (MS) analysis of tissues is currently used for profiling of known or search for new biomarkers in cancer-related studies. We plan to develop a novel method that significantly improves sensitivity, dynamics range, and throughput of MS-based tissue imaging. This high-throughput method will operate at atmospheric conditions and can be also applied for a characterization of proteins in 2D gels.

Principal Investigator:

Eugene Moskovets
443-539-1710
moskovets@apmaldi.com

Business Contact:

Arnold Lee
443-539-1710
alee@apmaldi.com
Small Business Information at Submission:

MASSTECH, INC.
6992 COLUMBIA GATEWAY DR, #200 COLUMBIA, MD 21046-2985

EIN/Tax ID: 152233315
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: Yes
HUBZone-Owned: No