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TOPIC 324 PHASE I 9 MONTH FUNDING; NOVEL IMAGING AGENTS T EXPAND TE CLINICAL…

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
Program Year/Program:
2013 / SBIR
Agency Tracking Number:
N43CA130059
Solicitation Year:
2013
Solicitation Topic Code:
NCI
Solicitation Number:
Small Business Information
ROCKLAND IMMUNOCHEMICALS, INC.
650 ENGLESVILLE ROAD BOYERTOWN, PA 19512-
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2013
Title: TOPIC 324 PHASE I 9 MONTH FUNDING; NOVEL IMAGING AGENTS T EXPAND TE CLINICAL TOOL
Agency: HHS
Contract: N43CA130059
Award Amount: $249,975.00
 

Abstract:

Medical imaging and targeted therapy are the central components in the clinical management of cancer patients. Rockland Immunochemicals, Inc. is teaming up with Abzyme Therapeutics LLC to develop novel imaging agents that can be used in both cancer diagnosis and targeted therapy. In this phase I proposal, high-affinity camelid single domain antibodies to three cancer biomarkers HER2, EGFR and mesothelin will be developed. The antibodies will be directionally conjugated to near-infrared spectrum fluorescentdyes. Properties of the nanobody, including in vivo clearance, rapid tumor accumulation, in vivo stability and bioavailability, will be investigated in tumor xenograft animal models. In the Phase II, selected antibodies will be conjugated with chelators for radiolabeling with metal radionuclides. Pharmacokinetic, pharmacodynamics, immunogenic and toxicological characteristics of agents will be investigated in animal models to obtain data necessary for filing an Investigational New Drug application. PUBLIC HEALTH RELEVANCE

Principal Investigator:

Carl Ascoli
800-656-7625
CARL.ASCOLI@ROCKLAND-INC.COM

Business Contact:

Carl Ascoli
800-656-7625
CARL.ASCOLI@ROCKLAND-INC.COM
Small Business Information at Submission:

ROCKLAND IMMUNOCHEMICALS, INC.
650 ENGLESVILLE ROAD BOYERTOWN, PA 19512-

EIN/Tax ID: 131986244
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No