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IGF;;OT;;IGF This SBIR phase II, contract is targeted towards completing the…

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
Program Year/Program:
2013 / SBIR
Agency Tracking Number:
N44AA130007
Solicitation Year:
2013
Solicitation Topic Code:
NIAAA
Solicitation Number:
Small Business Information
THERASOURCE, LLC
59 HIGHLAND AVE ROSLYN, NY 11576-2011
View profile »
Woman-Owned: No
Minority-Owned: Yes
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 2013
Title: IGF;;OT;;IGF This SBIR phase II, contract is targeted towards completing the prec
Agency: HHS
Contract: N44AA130007
Award Amount: $470,529.00
 

Abstract:

Despite advances in our understanding of excessive alcohol intake-related tissue injury, high morbidity and mortality due to infections in alcohol abusers remain a prominent challenge. Milk fat globule epidermal growth factor-factor VIII (MFG-E8) is involved in the clearance of apoptotic cells. We previously discovered that acute alcohol exposure and infections down regulate MFG-E8 expression. Administration of recombinant murine MFG-E8 (rmMFG-E8) reduces apoptosis, decreases inflammatory responses, and attenuates organ damage in a rat model of acute alcohol exposure and subsequent polymicrobial infections. However, one obstacle that hampered development of MFG-E8 as a therapeutic agent for alcoholic patients with infections is the potential immunogenicity of animal proteins in humans. To overcome this, we successfully expressed and purified recombinant human MFG-E8 (rhMFG-E8), and our data indicated that rhMFG-E8 is as effective as animal MFG-E8. In our SBIR Phase I Contract, we scaled up the production of recombinant human MFG-EB (rhMFG-EB) and confirmed the beneficial effect of rhMFG-EB in a rodent model of acute alcohol exposure and sepsis. The goal of this SBIR Phase II Contract is targeted towards completing the preclinical development of rhMFG-EB as a novel therapeutic agent in reducing mortality after alcohol/sepsis. PUBLIC HEALTH RELEVANCE

Principal Investigator:

Wayne Chaung
516-641-0196
WAYNE_CHAUNG@THERASOURCELLC.COM

Business Contact:

Wayne Chaung
516-641-0196
WAYNE_CHAUNG@THERASOURCELLC.COM
Small Business Information at Submission:

THERASOURCE, LLC
59 HIGHLAND AVE ROSLYN, NY 11576-2011

EIN/Tax ID: 120261881
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: Yes
HUBZone-Owned: No