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SBIR PHASE II TOPIC 294:SITE-SPECIFIC ANTIBODIES FOR GLCNACYLATED PROTEINS IN…

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
Program Year/Program:
2013 / SBIR
Agency Tracking Number:
N44CA130058
Solicitation Year:
2013
Solicitation Topic Code:
NCI
Solicitation Number:
Small Business Information
DETROIT R AND D, INC.
DETROIT R AND D, INC. DETROIT, MI 48201-
View profile »
Woman-Owned: Yes
Minority-Owned: Yes
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 2013
Title: SBIR PHASE II TOPIC 294:SITE-SPECIFIC ANTIBODIES FOR GLCNACYLATED PROTEINS IN CAN
Agency: HHS
Contract: N44CA130058
Award Amount: $989,975.00
 

Abstract:

O-GlcNAcylation of proteins plays a critical role in cell cycle regulation, apoptosis and signal transduction. Modification of O-GlcNAcylation of proteins by O-GlcNAc transferase is reversible by the activity of O-GlcNAcase. Addition and removal of O-GlcNAc moiety to serine or threonine regulate the function of proteins directly or via decreased phosphorylation. O-GlcNAcylation of c-myc proteins induces ubiquitin-dependent c-myc degradation. GlcNAcylation of p53 prevents p53 degradation and stabilizes p53 proteins, which are beneficial in cancer cells by arresting cell growth and inducing apoptosis in response to DNA damage. To elucidate functions of O-GlcNAcylation of the proteins it is necessary to develop site-specific antibodies for O-GlcNAcylated proteins. Few site-specific antibodies have been successfully produced so far. A lack of site-specific O-GlcNAcylated Abs prevents facile detection and quantitation of the site to elucidate the function of O-GlcNAcylated molecules in physiology and disease. Availability of O-GlcNAcylation site-specific antibodies will facilitate mechanistic studies on O-GlcNAcylation and phosphorylation-dependent signal transduction pathway in cancer, which will result in development of O-GlcNAcylation-inducing anti-cancer drugs. PUBLIC HEALTH RELEVANCE

Principal Investigator:

Hyesook Kim
248-539-3236
INFO@DETROITRANDD.COM

Business Contact:

Hyesook Kim
248-539-3236
INFO@DETROITRANDD.COM
Small Business Information at Submission:

DETROIT R AND D, INC.
DETROIT R AND D, INC. DETROIT, MI 48201-

EIN/Tax ID: 383375464
DUNS: N/A
Number of Employees: N/A
Woman-Owned: Yes
Minority-Owned: Yes
HUBZone-Owned: No