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Oral vaccine delivery of recombinant subunit vaccines for animal diseases

Award Information

Agency:
Department of Homeland Security
Branch:
N/A
Award ID:
Program Year/Program:
2014 / SBIR
Agency Tracking Number:
HSHQDC-14-R-00005-H-SB014.1-002-0001-I
Solicitation Year:
2014
Solicitation Topic Code:
H-SB014.1-002
Solicitation Number:
HSHQDC-14-R-00005
Small Business Information
VST LLC dba Medgene Labs
1006 32nd Avenue Suite 104 Brookings, SD 57006-4728
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2014
Title: Oral vaccine delivery of recombinant subunit vaccines for animal diseases
Agency: DHS
Contract: HSHQDC-14-C-00024
Award Amount: $99,999.05
 

Abstract:

Wildlife are a reservoir of diseases affecting both humans and domestic animals. These wildlife reservoirs represent a potential threat to public health, serving as a continuous and difficult to eradicate source of infection for zoonotic diseases, but may also represent a significant economic threat to US agriculture. In particular, wild ruminants including white-tail deer may harbor vector-borne infectious diseases that can directly impact US Cattle and Sheep operations. Medgene Labs focuses on the development of novel subunit vaccine formulations to address these critical diseases that may affect both public health and US agricultural animals. Subunit vaccines have the advantage of being highly stable and safe from potential reversion to virulence, supporting strong protective immune responses without the potential for contributing to new outbreaks through combination with wild-type agents. Furthermore, these strategies are ideally suited to the development of immune responses to effectively differentiate vaccinated from infected animals (DIVA approach). Our current development efforts have defined highly efficacious, DIVA-compatible vaccine formulation directed against Rift Valley Fever Virus, and a focus of this proposal is to define an efficacious oral vaccine. This proposal will leverage the existing strength that Medgene Labs brings to the generation of highly effective and safe vaccine strategies directed against RVFV and other orbiviruses of national interest to define appropriate delivery systems for oral vaccination of wildlife. Following initial characterization of these oral formulations in a well-established sheep model, we will proceed directly in Phase II to define efficacy in target cervid populations for use in wild ruminants.

Principal Investigator:

Ashley Petersen
Project Leader
(605) 692-1268
ashley@medgenelabs.com

Business Contact:

Alan J. Young
Chief Scientific Officer
(605) 695-1105
alan@medgenelabs.com
Small Business Information at Submission:

VST LLC dba Medgene Labs
1006 32nd Avenue Suite 104 Brookings, SD 57006-4728

EIN/Tax ID: 273314992
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No