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Brain-activity during sedation predicting post-sedation explicit-memory

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
93812
Program Year/Program:
2009 / SBIR
Agency Tracking Number:
GM086927
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
ABRATECH CORPORATION
ABRATECH CORPORATION 475 GATE 5 RD, STE 213 SAUSALITO, CA -
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2009
Title: Brain-activity during sedation predicting post-sedation explicit-memory
Agency: HHS
Contract: 1R43GM086927-01A2
Award Amount: $437,343.00
 

Abstract:

DESCRIPTION (provided by applicant): This project will study electrical brain-activity measures that may be able to indicate whether or not long-term memory is occurring, under light sedation. The goal is to develop a brain-monitor to be used in the operat ing room to ascertain if a patient's level of anesthesia has become too light, such that the patient can experience pain, and understand what is occurring in the operating room, and remember the experience. Such an event is rare, but traumatic. No present brain-analysis system accurately distinguishes the boundary in light anesthesia, between that level in which there will be explicit-memory and that level in which explicit-memory is missing. The fundamental scientific goal is to provide a tool for further investigations of the mechanisms of explicit memory, in animals as well as humans. If the goal were achieved, it would offer the chance to develop a clinical tool for analysis, diagnosis, or prognosis of medical conditions involving changes in memory (for which present tools are often inadequate). The project is health-related in that it addresses a problem in clinical medicine, and will provide a solution to that problem, if successful. PUBLIC HEALTH RELEVANCE: This project is relevant to public health bec ause it studies humans and their reactions to sedation under anesthetic agents, to find a way to detect whether, in an operation, the patient is alert enough to remember experiences. This is a rare event in surgery, but should be prevented, if possible, wi th the techniques that will be developed in this research.

Principal Investigator:

Don L. Jewett
4153318775
DLJ@ABRATECH.COM

Business Contact:

Don L. Jewett
dlj@abratech.com
Small Business Information at Submission:

ABRATECH CORPORATION
ABRATECH CORPORATION 475 GATE 5 RD, STE 213 SAUSALITO, CA 94965

EIN/Tax ID: 900215425
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No