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Development of Antibodies for the Detection of 2-Methylisoborneol (MIB) by…

Award Information

Department of Agriculture
Award ID:
Program Year/Program:
2002 / SBIR
Agency Tracking Number:
Solicitation Year:
Solicitation Topic Code:
Solicitation Number:
Small Business Information
54 STEAM WHISTLE DR Warminster, PA 18974-1450
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Woman-Owned: No
Minority-Owned: Yes
HUBZone-Owned: No
Phase 1
Fiscal Year: 2002
Title: Development of Antibodies for the Detection of 2-Methylisoborneol (MIB) by Immunoassay
Agency: USDA
Contract: 2002-33610-11945
Award Amount: $79,919.00


The aquaculture industry considers off-flavor in catfish to be one of the biggest problems facing the industry and representing a significant cost to catfish farmers and processors due to the unmarketability of the fish that have acquired these distasteful compounds. To avoid marketing fish with off-flavor, fish are screened for flavor quality before harvesting. Current quantitative chemical analysis is inadequate for flavor quality control because of time constraints and the high cost involved. Another technique utilizing human flavor testers is sensory analysis, although rapid and relative inexpensive, human assessment is prone to errors due to sickness, fatigue and variability among testers. In this work we propose to develop and produce monoclonal and polyclonal antibodies which react with 2-methylisoborneol (MIB) with sufficient selectivity, affinity, and avidity to be utilized in a low cost and rapid commercial immunoassay system, which ultimately benefit farmers, processors and consumers by ensuring a high quality product. Production of these antibodies is described including the immunogens, injection schedule, screening process, hybridoma development, polyclonal and monoclonal selection criteria.

Principal Investigator:

Fernando M. Rubio

Business Contact:

Fernando M. Rubio
Small Business Information at Submission:

Abraxis, LLC
2935 Byberry Road Hatboro, PA 19040

EIN/Tax ID: 233004797
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No