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Burkholderia antibody molecules for therapeutics and diagnostics

Award Information

Agency:
Department of Defense
Branch:
Office for Chemical and Biological Defense
Award ID:
Program Year/Program:
2014 / SBIR
Agency Tracking Number:
C141-105-0056
Solicitation Year:
2014
Solicitation Topic Code:
CBD14-105
Solicitation Number:
2014.1
Small Business Information
BIOO Scientific
7050 Burleson Rd. Austin, TX 78744-3202
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2014
Title: Burkholderia antibody molecules for therapeutics and diagnostics
Agency / Branch: DOD / CBD
Contract: W911QY-14-P-0160
Award Amount: $99,846.00
 

Abstract:

Burkholderia pseudomallei and Burkholderia mallei are highly pathogenic Gram-negative bacteria and the causative agents of melioidosis and glanders, respectively. These infections, which occur in humans and other animals, are endemic is wide regions of the developing world. Translational research regarding these pathogens is focused on developing new strategies to detect, treat and ideally protect humans and animals from these infections. In this Phase I SBIR project, we will establish methodologies for the generation of monoclonal antibodies that have high-affinities to Burkholderia antigens. The purpose of these studies is to create new antibody-based prophylactics that can neutralize Burkholderia infections. As a first step, we will isolate carbohydrate antigens from non-pathogenic strains of Burkholderia in forms that will generate appropriate immune responses. We will also assess the relative performance and compatibilities of existing antibodies to bind Burkholderia pathogens, in order to create optimized formulations, which will be assessed for therapeutic benefit in future challenge studies.

Principal Investigator:

Sandesh Subramanya
Director, Animal Health
(512) 707-8993
sandeshs@biooscientific.com

Business Contact:

Lance P. Ford
Manager of Sponsored Research
(512) 707-8993
lford@biooscientific.com
Small Business Information at Submission:

BIOO Scientific
7050 Burleson Rd. Austin, TX 78744-3202

EIN/Tax ID: 870781699
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No