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Non-invasive Detection System for Assessment of Oxidative Status

Award Information

Department of Defense
Award ID:
Program Year/Program:
2014 / SBIR
Agency Tracking Number:
Solicitation Year:
Solicitation Topic Code:
Solicitation Number:
Small Business Information
ChromoLogic LLC
1225 Shamrock Ave Pasadena, CA 91016-4244
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Phase 2
Fiscal Year: 2014
Title: Non-invasive Detection System for Assessment of Oxidative Status
Agency: DOD
Contract: W911QY-14-C-0003
Award Amount: $499,889.00


To address the Army"s need for a non-invasive, compact, robust system to monitor the oxidative status of military personnel, ChromoLogic (CL) proposed and demonstrated during Phase I a OCular Oxidative Stress Monitor (OCOSMO) system based on non-invasive optical measurements of oxidative stress biomarkers that are expressed within the aqueous humor (eye). By building multiple generations of OCOSMO prototypes and performing in vitro tests, CL demonstrated for the first time that cost-effective non-invasive monitoring of oxidative stress biomarkers in real-time is highly feasible. A high specificity panel of biomarkers was identified for determining oxidative stress caused from exercise. Tests with the OCOSMO prototypes showed that these biomarkers can be identified with sensitivity>10x the clinical level needed. In Phase II, CL plans to develop a complete OCOSMO prototype and perform detailed pre-clinical and clinical validation of the technology.

Principal Investigator:

Mark Mackanos
Research Scientist
(626) 381-9974

Business Contact:

Naresh Menon
(626) 381-9974
Small Business Information at Submission:

ChromoLogic LLC
180 N Vinedo Ave Pasadena, CA 91107-

EIN/Tax ID: 203048938
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No