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Oligonucleotide Enzyme Surrogate (OnES)

Award Information

Agency:
Department of Defense
Branch:
Office for Chemical and Biological Defense
Award ID:
86066
Program Year/Program:
2008 / SBIR
Agency Tracking Number:
C081-108-0102
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Accacia International LLC
One Tech Plaza 2113 Wells Branch Parkway, Suite 6900 Austin, TX -
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2008
Title: Oligonucleotide Enzyme Surrogate (OnES)
Agency / Branch: DOD / CBD
Contract: FA8650-08-M-6915
Award Amount: $69,963.00
 

Abstract:

Historically organophosphorus compounds such as insecticides and nerve agents have been susceptible to decomposition by proteinaceous enzymes. Organophosphate hydrolases (OPH) represent a practical method to deactivate such compounds peripherally and on surfaces. However, when such organophosphates are ingested, the use of proteinaceous enzymes such as OPH can be problematic because of their tendency to produce an immune response. In order to avoid this issue, Accacia International will manipulate DNA oligonucleotides using a novel and innovative selection method. DNA aptamers will be selected through the Systematic Evolution of Ligands by EXponential enrichment (SELEX) method to accomplish the task of creating an enzyme surrogate.

Principal Investigator:

Jean Bishop
Principal Investigator
5126173387
jean@accaciabio.com

Business Contact:

Austin Sequeira
Director
5127828204
austin@accaciabio.com
Small Business Information at Submission:

ACCACIA INTERNATIONAL, INC.
One Tech Plaza 2113 Wells Branch Parkway, Sui Austin, TX 78728

EIN/Tax ID: 742971514
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No