A BIOMATERIAL FOR ESOPHAGEAL REPAIR
DESCRIPTION (Unedited Applicant's Abstract):When people with diabetes reach
end-stage renal disease they must undergo either dialysis or transplantation.
About 200,000 Americans need artificial kidney machines to stay alive. These
machines rely on sterile dialysis membranes to remove toxic materials from the
bloodstream. More than 30 different polymers or polymer blends are used in
dialysis membranes, and most of these degrade under conditions of steam or
gamma radiation sterilization. Ethylene oxide (EO) remains the sterilant of
choice for these membranes. However, the traditional blend used 88 percent
CFC-12 as a fire suppressant and propellant, and CFCs have been phased out of
production because of their high ozone-depletion potentials (ODPs).
Alternatives include explosive 100 percent EO and blends of EO with high global
warming potential (GWP) hydrofluorocarbons (HFCs), less effective carbon
dioxide, or hydro chlorofluorocarbon (HCFC) compounds facing future phase out.
This proposed Phase I effort wilt determine the feasibility of using blends
containing EO, trifluoromethyl iodide (CF3I), and HFCs for sterilizing dialysis
membranes. Trifluoromethyl iodide is an excellent combustion suppressant and
has physical properties similar to CFC-12 with zero ODP and extremely low GWP.
Flammability and fractionation tests will be conducted to determine optimal
blend compositions. Compatibility and residual CF3I measurements with common
membrane materials will be conducted.
PROPOSED COMMERCIAL APPLICATION:
The research, if successful, will develop a new nonflammable sterilant gas for dialysis
membranes that does not contain ozone-depleting substances, is more effective that
current alternatives, and has reduced GWP. The new sterilant gas should also be useful
for sterilizing many other types of medical equipment. The new sterilant gas should be
marketable worldwide and should allow use of existing EO sterilizing equipment, thus
reducing costs of medical care.
Small Business Information at Submission:
Principal Investigator:Alan R. Spievack
6 OLD DEE RD CAMBRIDGE, MA 02138
Number of Employees: