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Three Dimensional ECM Scaffolds for Tissue Engineering

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
71574
Program Year/Program:
2004 / SBIR
Agency Tracking Number:
DK069110
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
ACELL, INC.
6 OLD DEE ROAD CAMBRIDGE, MA 02138
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2004
Title: Three Dimensional ECM Scaffolds for Tissue Engineering
Agency: HHS
Contract: 1R43DK069110-01
Award Amount: $100,000.00
 

Abstract:

DESCRIPTION (provided by applicant): This Phase I SBIR application seeks support to develop a three dimensional acellular scaffold composed of particulate extracellular matrix (ECM). Products composed of the two dimensional (sheet form) of ECM derived from porcine urinary bladder have been marketed by ACell in the field of veterinary medicine and have received regulatory approval for entry into the human market. The physical limitations of a two dimensional from which to manufacture devices dictates that strategies for constructing three dimensional scaffolds be developed. Three Specific Aims in this development process are included in this proposal: #1 - to characterize the size and shape distribution of ECM particles that are manufactured by two different test methods; #2. to create 2 cm tubed scaffolds from ECM particles which have a minimum suture retention strength of 9.0 N; and finally, #3 - to evaluate the ability of two separate cell types to proliferate upon and invade (migrate into) a 2 cm tubed scaffold constructed of ECM particles. Successful completion of these Specific Aims will result in manufacturing methods that assure uniform and consistent three dimensional scaffolds that have the physical properties that will enable their clinical use and the biocompatibility that will support constructive remodeling in patients. The study to complete the three Specific Aims will be conducted by an experienced interdisciplinary group of scientists along a time line that is clearly described and with measurable endpoints.

Principal Investigator:

Alan R. Spievack
6175479060
ARSPIEVACK@COMCAST.NET

Business Contact:

Alan Spievack
6175479060
ARSPIEVACK@COMCAST.NET
Small Business Information at Submission:

ACELL, INC.
6 OLD DEE ROAD CAMBRIDGE, MA 02138

EIN/Tax ID: 043496380
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No