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COMBINATORIAL BIOSYNTHESIS OF NOVEL BIOREDUCTIVE AGENTS

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
60987
Program Year/Program:
2002 / SBIR
Agency Tracking Number:
GM062691
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
ACERA BIOSCIENCES, INC.
ACERA BIOSCIENCES, INC. 603 E LAKE ST, STE 200F WAYZATA, MN 55391
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2002
Title: COMBINATORIAL BIOSYNTHESIS OF NOVEL BIOREDUCTIVE AGENTS
Agency: HHS
Contract: 1R43GM062691-01A2
Award Amount: $148,400.00
 

Abstract:

DESCRIPTION (provided by applicant): The structural and biosynthetic similaritybetween FR900482 and mitomycin (MC) group of antitumor antibiotics makes it promising to rationally create novel mitomycin/FR900482 hybrids through combinatorial biosynthesis. After successful identification of both MC and FR900482 biosynthetic gene clusters, Acera Biosciences now sets to create such potent bioreductive agents through manipulating these pathways. The long-term goal is to generate large libraries of novel hybrids to eventually find compounds with increased tumor specificity and reduced systemic toxicity. The specific aims in this project include 1). Production of novel C6 methyl FR900482 derivatives by MC carbonyl reduction enzyme Mmcl. 2). Creation of novel chimeric MC/FR900482 hybrids. 3). Development of a multiplasmid system for further biosynthetic pathway design. Dozens of novel MC/FR900482 hybrids are expected to be generated in this proposal. The compounds with MC quinone and FR900482 hemiketal functions will be of special interests for making more potent anticancer agents.

Principal Investigator:

Yingqing Mao
6126251901
YMAO@ACERABIO.COM

Business Contact:

David Taus
9524754929
Small Business Information at Submission:

ACERA BIOSCIENCES, INC.
ACERA BIOSCIENCES, INC. 603 E LAKE ST, STE 200F WAYZATA, MN 55391

EIN/Tax ID: 411944324
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No