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Non-Invasive Drug Delivery to Treat Posterior Uveitis

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
70820
Program Year/Program:
2004 / SBIR
Agency Tracking Number:
EY014772
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
ACIONT, INC.
350 WEST 800 NORTH, STE 320 SALT LAKE CITY, UT 84103-
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2004
Title: Non-Invasive Drug Delivery to Treat Posterior Uveitis
Agency: HHS
Contract: 1R43EY014772-01A2
Award Amount: $133,202.00
 

Abstract:

Intermediate and posterior uveitis cause 10% of blindness in the U.S. The mainstay of therapy is to eradicate the infectious cause and to quell the inflammation with corticosteroids or immunosuppressants. Delivery of anti-inflammatory drugs to the posterior portion of the globe in therapeutic concentrations has proven difficult. There are four methods of delivering compounds to the posterior chamber: intravitreal injection, oral administration with subsequent distribution into the eye through optic blood flow, peribulbar injection, and passive diffusion through the sclera following topical application. Each method has its well-known drawbacks. This proposal will study non-invasive drug delivery to the posterior portion of the rabbit's eye. Specific aims include studying the passive permeability of a corticosteroid and mechanisms to enhance non-invasive transscleral delivery to the posterior retina. Included in these mechanisms are means to decrease conjunctival and choroidal pre-retinal clearance. Lastly, once we have determined the formulation and conditions that maximize corticosteroid delivery, we will study in vivo effectiveness of our technique in the treatment of endotoxin-induced uveitis in the rabbit model.

Principal Investigator:

David J. Miller
8013593461
DMILLER@ACIONT.COM

Business Contact:

John Higuchi
8013593461
JWH@ACIONT.COM
Small Business Information at Submission:

ACIONT, INC.
ACIONT, INC. 350 WEST 800 NORTH, STE 250 SALT LAKE CITY, UT 84103

EIN/Tax ID: 943356125
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No