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Quantitative C-arm Fluoroscopy - Prostate Brachytherapy

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
65443
Program Year/Program:
2006 / SBIR
Agency Tracking Number:
CA099374
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
BURDETTE MEDICAL SYSTEMS, INC.
BURDETTE MEDICAL SYSTEMS, INC. 206 N. RANDOLPH ST., SUITE 300 CHAMPAIGN, IL 61820 0397
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 2006
Title: Quantitative C-arm Fluoroscopy - Prostate Brachytherapy
Agency: HHS
Contract: 2R44CA099374-02A1
Award Amount: $1,444,683.00
 

Abstract:

DESCRIPTION (provided by applicant): Prostate cancer continues to be a significant health problem, both domestically and worldwide. Numerous studies have demonstrated the efficacy and safety of transperineal prostate brachytherapy in the therapy of prostate cancer. The success of brachytherapy chiefly depends on our ability to intra-operatively tailor the radiation dose to the patient's individual anatomy. Thus the objective of this research is to design, develop, and clinically test a method for intra-operative localization of the implanted seeds in relation to the prostate, to allow for intra-operative dosimetric optimization and exit dosimetry. Brachytherapy is predominantly performed with transrectal ultrasound guidance, which provides adequate real-time visualization of soft tissue anatomy, but does not show the implanted seeds. To overcome this problem, we propose registration of ultrasound to intra-operative C-arm fluoroscopy, where the implanted seeds will be reconstructed from fluoroscopy and superimposed on ultrasound. In particular, we will: (1) Design a system and workflow that is consistent with contemporary practice of prostate brachytherapy. (2) Develop optimized mathematical algorithms for reconstruction of seed implants from C-arm fluoroscopy images, spatial registration of fluoroscopy and ultrasound imaging. (3) Integrate the algorithms with an existing commercial prostate brachytherapy system and implant optimization methods. (4) Conduct Clinical System Performance Evaluation Trial on human patients. We have established the technical feasibility of this approach in a Phase-1 SBIR research grant. We are requesting Phase-2 support to develop a clinical-grade system and evaluate its technical performance on human patients. The resulting system will withstand the scrutiny of subsequent FDA approval and enter wide-spread clinical use via commercial dispersion.

Principal Investigator:

Everette C. Burdette
2173554460
clifb@acousticmed.com

Business Contact:

Everette Burdette
2177780900
CLIFB@SHOUT.NET
Small Business Information at Submission:

BURDETTE MEDICAL SYSTEMS, INC.
BURDETTE MEDICAL SYSTEMS, INC. 206 N. RANDOLPH ST., SUITE 300 CHAMPAIGN, IL 61820

EIN/Tax ID: 371361909
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No