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Company Information:

Name: Active Motif, Inc.
Address: 1914 Palomar Oaks Way
Suite 150
Carlsbad, CA 92008-6509
Located in HUBZone: No
Woman-Owned: No
Minority-Owned: No
URL: N/A
Phone: (760) 431-1263

Award Totals:

Program/Phase Award Amount ($) Number of Awards
SBIR Phase I $1,440,790.00 12

Award List:

A Novel Approach to mRNA Isolation using PNAs

Award Year / Program / Phase: 2001 / SBIR / Phase I
Agency: HHS
Principal Investigator: Dorothy M. Archdeacon
Award Amount: $93,197.00
Abstract:
DESCRIPTION (Applicant's abstract): Peptide nucleic acids (PNAs) have a number of features that suggest they would be ideal probes for purifying mRNA. In this revised format we have demonstrated the use of phosphono PNAs (pPNAs) in an RNA isolation procedure that improves the… More

Novel 5'-end tagging of mRNA for cDNA synthesis or RACE

Award Year / Program / Phase: 2001 / SBIR / Phase I
Agency: HHS
Principal Investigator: John Archdeacon
Award Amount: $92,662.00
Abstract:
DESCRIPTION (Applicant's abstract): In this application we will discuss the rationale for the development of a novel method for chemically tagging a synthetic oligonucleotide to the 5'-end of full-length mRNAs using the cap structure (7-methyl guanosine triphosphate,… More

Isothermal Amplification for Detection of Nucleic Acids

Award Year / Program / Phase: 2001 / SBIR / Phase I
Agency: HHS
Principal Investigator: Dorothy M. Archdeacon
Award Amount: $96,594.00
Abstract:
In this proposal we discuss the development of a technique to amplify the signal generated when a labeled chimeric oligonucleotide hybridizes to it target sequence. Clearly there is a huge need for such a technique given the amount of variability that occurs during triditional amplification… More

Novel Protein Array Based on Binary Coded Microchips

Award Year / Program / Phase: 2001 / SBIR / Phase I
Agency: HHS
Principal Investigator: Herve Lecalvez
Award Amount: $97,573.00
Abstract:
DESCRIPTION (provided by applicant): The overall experimental approach of this proposal is targeted to design an innovative format for arraying proteins. Instead of using the common glass slide or nitrocellulose membrane to spot proteins onto, we proposed to use a silica… More

MULTIWELL COLORIMETRIC ASSAY FOR DNA REPAIR PROTEIN.

Award Year / Program / Phase: 2002 / SBIR / Phase I
Agency: HHS
Principal Investigator: Jacques T. Weissman
Award Amount: $99,380.00
Abstract:
DESCRIPTION (provided by applicant): DNA damages are key events during carcinogenesis. Deficiencies in repairing damaged DNA represent a poor prognosis during tumorigenesis and/or cancer treatment. Besides monitoring DNA damage formation, it would be helpful to monitor DNA repair protein activity.… More

FLUOROGENIC IMAGING MOLECULES FOR PROTEASE/KINASE ASSAYS

Award Year / Program / Phase: 2002 / SBIR / Phase I
Agency: HHS
Principal Investigator: John Archdeacon
Award Amount: $99,145.00
Abstract:
DESCRIPTION (provided by applicant): The aim of this proposal is to develop a series of fluorogenic imaging molecules, which can be easily delivered into viable cells and monitor cellular functions. The FIMs are composed of a peptide backbone containing a target site for a kinase or a protease. Some… More

NOVEL SP1 & ER DNA-BINDING ASSAY FOR CANCER PROGNOSIS

Award Year / Program / Phase: 2002 / SBIR / Phase I
Agency: HHS
Principal Investigator: Haizhen Liu
Award Amount: $99,215.00
Abstract:
DESCRIPTION (provided by applicant): This proposal focuses on the development of multi-well ELISA-like assays to quantify DNA binding activity of two breast cancer prognosis markers, Sp1 and ER, with much more sensitivity and high throughput than standard DNA gel shift techniques. Such an approach… More

In vivo transcription factor DNA binding analysis

Award Year / Program / Phase: 2003 / SBIR / Phase I
Agency: HHS
Principal Investigator: John Archdeacon
Award Amount: $99,850.00
Abstract:
DESCRIPTION (provided by applicant): Currently, there exist a number of methods for the study of transcription factors and gene-promoter activity. These include reporter gene assays, gel shift assays, and expression-profiling methods such as microarray analysis and SAGE. These methods are well… More

Novel conformation-based nuclear receptor activity assay

Award Year / Program / Phase: 2003 / SBIR / Phase I
Agency: HHS
Principal Investigator: John Archdeacon
Award Amount: $99,500.00
Abstract:
DESCRIPTION (provided by applicant): The objective of this proposal is the development of novel methods for the study of the Class II Nuclear Receptors Thyroid hormone receptor (TR), Retinoic Acid Receptor (RAR), and Vitamin D3 Receptor (VDR). Like other members of the nuclear receptor superfamily,… More

High throughput assay for small G protein activation

Award Year / Program / Phase: 2005 / SBIR / Phase I
Agency: HHS
Principal Investigator: Jacques Weissman
Award Amount: $99,600.00
Abstract:
DESCRIPTION (provided by applicant): The small GTP binding protein superfamily (consisting of small, monomeric GTP hydrolyzing proteins or GTPases) regulates diverse cellular processes including gene expression, cellular proliferation, cytoskeletal reorganization, vesicle trafficking, and… More

Chromatin Immunoprecipitation (ChIP) Assay Development for FFPE human brain secti

Award Year / Program / Phase: 2010 / SBIR / Phase I
Agency: HHS
Principal Investigator: Mary A. Jelinek
Award Amount: $314,074.00
Abstract:
DESCRIPTION (provided by applicant): Depression is the leading cause of disability among individuals between the ages of 15-44, affecting approximately 21 million Americans and is the leading cause of suicide. Current diagnostic tools available for medical professionals are limited to… More

SBIR Phase I: High-throughput multi-analyte ChIP Assay Development

Award Year / Program / Phase: 2012 / SBIR / Phase I
Agency: NSF
Principal Investigator: MaryAnne Jelinek
Award Amount: $150,000.00
Abstract:
This Small Business Innovation Research (SBIR) Phase I project proposes to develop a high-throughput, multi-analyte chromatin immunoprecipitation (ChIP) system. ChIP is a widely used technique among life science and biomedical researchers seeking map the specific DNA sequences that are bound by a… More