DESCRIPTION (provided by applicant): Chemical probes will be developed to profile toxicities resulting from drug interactions. We have developed fluorescent probes that exclusively identify active members of the serine hydrolase super-family of enzymes. Using our technique, we can elucidate activity… More

DESCRIPTION (provided by applicant): ActivX Biosciences (ActivX) will develop and validate a novel toxicoproteomics platform to correlate changes in protein activity with compound toxicology. This platform uses fluorescent chemical probes to interrogate catalytically active proteins related by… More

DESCRIPTION (provided by applicant): Activity-based probes (ABPs) for broad protein families will be used to establish protein-based activity profiles for the diagnosis/prognosis/staging of breast cancer and identification of new markers that can be used for more rapid clinical testing. Breast… More

DESCRIPTION (provided by applicant): Activity-based probes (ABPs) for broad protein families will be used to identify novel protein targets and small molecule leads relevant to ovarian cancer. Because ovarian cancer is often asymptomatic during its early and most treatable stages, it is… More