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System for Multiplex Protein:Protein Interaction Studies Modeled with Antibodies

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R43GM112385-01
Agency Tracking Number: R43GM112385
Amount: $222,500.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: NIGMS
Solicitation Number: PA13-234
Timeline
Solicitation Year: 2014
Award Year: 2014
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
688 E MAIN ST, STE 2A
BRANFORD, CT 06405-2971
United States
DUNS: 78402317
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 MICHAEL WEINER
 (203) 458-2844
 mweiner@axiomxinc.com
Business Contact
 MICHAEL WEINER
Phone: (203) 606-5394
Email: mweiner@axiomxinc.com
Research Institution
 Stub
Abstract

DESCRIPTION (provided by applicant): The overarching goal of Phase I is to produce a method that will generate, identify and clone a catalog of protein-protein interactions in a single rapid experiment. In this proposal we will model the technology using antibody-antigen interactions. Recombinant antibody libraries against a proteome could be produced prior to any need, and then desired affinity reagents systematically cloned as needed. Libraries of recombinational biopanning integration product against a proteome could also be distributed along with primer sets against a set of barcodes for facile cloning. In future endeavors, the method will be used to clone tumor-cell or other diseased tissue cDNAs to use as an epitope library to quickly identify potential biomarkers. Successful completion of this phase will allow th commercialization of antibodies that can be used for diagnostic and therapeutic applications at a speed and comprehensiveness that is not easily achieved by current methods. Kits composed

* Information listed above is at the time of submission. *

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