An Official Website of the United States Government
Drug discovery of anti-ADDL therapeutics for Alzheimer's
- Small Business Information
-
Acumen Pharmaceuticals, Inc.Acumen Pharmaceuticals, Inc. 385 Oyster Point Blvd. South San Francisco, CA 94080View profile »Woman-Owned: NoMinority-Owned: NoHUBZone-Owned: No
- Phase 1
-
Fiscal Year: 2005Title: Drug discovery of anti-ADDL therapeutics for Alzheimer'sAgency: HHSContract: 1R43AG026951-01Award Amount: $183,750.00
Abstract:
DESCRIPTION (provided by applicant): Recent evidence suggests that the primary cause of Alzheimer's disease is the progressive accumulation of neurotpxic oligomeric assemblies of the Abeta 1-42 protein. These neurotoxic oligomeric species are known as ADDLs (Ab-derived diffusible ligands). In Tg2576 AD mice, a transgenic Alzheimer's disease animal model, memory performance declines as ADDL levels increase. Human patients with Alzheimer's disease show a 70-fold elevation in ADDL levels relative to unaffected age-matched controls. ADDLs affect memory by directly interfering with synaptic function, which eventually results in synaptic loss over time. This evidence suggests that small molecule, ADDL-directed therapeutics might prevent ADDL-induced cognitive deficits, and slow or reverse disease progression in humans. This stands in contrast to current FDA-approved drugs, which treat the symptoms and not the underlying cause of Alzheimer's disease. The most promising approach to ADDL-directed therapeutics is to prevent ADDL formation by blocking assembly of the Abeta 1-42 protein. The subject of this proposal is to establish and validate a cascade of primary and secondary chemical screens and screen a representative CNS targeted chemical library to identify small molecules that block ADDL assembly. In Phase I, we propose to develop and validate a homogeneous ADDL assembly blocker screening assay, conduct molecular dynamics simulations to build an ADDL structural model, and carry out pilot screening of a selected small molecule library.Small Business Information at Submission:Acumen Pharmaceuticals, Inc.
Acumen Pharmaceuticals, Inc. 385 Oyster Point Blvd. South San Francisco, CA 94080EIN/Tax ID: 364108129DUNS: N/ANumber of Employees: N/AWoman-Owned: NoMinority-Owned: NoHUBZone-Owned: No
Award Information
|
Agency: Department of Health and Human Services |
Branch: N/A |
Award ID: 75819 |
Program Year/Program: 2005 / SBIR |
|
Agency Tracking Number: AG026951 |
Solicitation Year: N/A |
Solicitation Topic Code: N/A |
Solicitation Number: N/A |