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Multi-functional particles for stem cell isolation and expansion

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R41MH106303-01
Agency Tracking Number: R41MH106303
Amount: $200,251.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: NIMH
Solicitation Number: PA13-089
Timeline
Solicitation Year: 2014
Award Year: 2014
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
1917 PARKTREE DR
ARLINGTON, TX 76001-5689
United States
DUNS: 780329913
HUBZone Owned: No
Woman Owned: Yes
Socially and Economically Disadvantaged: No
Principal Investigator
 WENJING HU
 (817) 466-3807
 wenjing.hu@progenitec.com
Business Contact
 WENJING HU
Phone: (682) 365-8775
Email: wenjing.hu@progenitec.com
Research Institution
 UNIVERSITY OF TEXAS ARLINGTON
 
UNIVERSITY OF TEXAS ARLINGTON Arlington Technology Incubator 202 E BORDER
ARLINGTON, TX 76019-0145
United States

 () -
 Nonprofit College or University
Abstract

DESCRIPTION (provided by applicant): The objective of this STTR Phase I proposal is to develop novel multi-layer microparticles and demonstrate their feasibility to isolate and expand stem cells for medical research and therapeutic applications. In recentyears, stem cells have been used in a wide variety of applications, including cell- based therapies, drug screening, and models to understand the disease development. Unfortunately, many of these applications require large number of stem cells which cannotbe produced by most of the current cell isolation and culture methods. The limitations of the current methods include the use of harmful chemicals and enzymes for cell isolation and expansion, and harsh shear forces from centrifugation during cell passaging process. To overcome these drawbacks, we will develop novel multi-layer microparticles that allow stem cell isolation via magnetic separation, cell attachment using a temperature-sensitive mechanism that binds cells at 370C, cell expansion via 3-D

* Information listed above is at the time of submission. *

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