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Plasmodium Genus and PFV Fluorescent In Situ Hybridization (FISH) Assay Kit for d

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 2R44AI056785-04
Agency Tracking Number: R44AI056785
Amount: $885,321.00
Phase: Phase II
Program: SBIR
Solicitation Topic Code: NIAID
Solicitation Number: PA13-088
Timeline
Solicitation Year: 2014
Award Year: 2014
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
926 E. RIVER PARKWAY
SANTA CLARA, CA 95054-4141
United States
DUNS: 603207106
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 JYOTSNA SHAH
 (408) 969-0079
 jyotsna@aol.com
Business Contact
 JYOTSNA SHAH
Phone: (408) 969-0079
Email: jyotsna@aol.com
Research Institution
 Stub
Abstract

DESCRIPTION (provided by applicant): Malaria can be a life-threatening disease, especially in children, if left untreated. According to WHO, 525,000 to 2.0 million African children die from Malaria every year. The current gold standard for diagnosis is examination of Giemsa stained smear by microscopy. However, when parasite levels are very low, or in mixed infections, the information obtained by examination of Giemsa stained smear by microscopy is limited. Under SBIR Phase II we have developed 3 kits, P-Genus, PF and PV FISH assay kits. These kits detect malaria parasites on blood smears prepared with a special reagent by Fluorescent in Situ Hybridization (FISH) technique, using specific fluorescent labeled DNA probes targeted to ribosomal RNA of viable parasites. P- Genus kit detects all species of Plasmodium. PF-FISH kit and PV-FISH kit detect and differentiate P. falciparum and P. vivax from other species of Plasmodium respectively, on any P-Genus screen positive blood sample. Since ribosomal RNA is

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