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Novel 3-dimensional platform for high-throughput glycomics discovery

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
85958
Program Year/Program:
2007 / SBIR
Agency Tracking Number:
RR023763
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
ADA Technologies, Inc.
8100 Shaffer Parkway Suite #130 Littleton, CO -
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2007
Title: Novel 3-dimensional platform for high-throughput glycomics discovery
Agency: HHS
Contract: 1R43RR023763-01
Award Amount: $101,824.00
 

Abstract:

DESCRIPTION (provided by applicant): Glycomics is an emerging field that focuses on studying the interactions of carbohydrates with other biopolymers, particularly proteins, to gain a better understanding of the roles of carbohydrates in biological process es. Carbohydrate microarray technologies represent a new development at the frontier of glycomics. Microarrays of carbohydrates (glycoconjugates, polysaccharides, oligosaccharides and monosaccharides) allow high-throughput, parallel analyses. Parallel anal yses greatly facilitate not only surveys of proteins for carbohydrate-binding activities but also elucidation of their ligands. However, there is a lack of technology for the fabrication of high quality carbohydrate microarrays for high-throughput analysis of glycomes because of the difficulty to reliably immobilize populations of chemically and structurally diverse glycans. ADA proposes to develop aminooxy- and hydrazide-functionalized dendrimer monolayer films on solid substrates for covalent, site-specif ic immobilization of unmodified carbohydrate probes. Miniaturized microwave radiation energy will also be evaluated for quick and convenient immobilization of the polysaccharides on the proposed slide platform. The resulting platforms will allow facile and effective fabrication of carbohydrate microarrays. The proposed novel slide platform will significantly increase the efficiency of glycan analysis and meet the growing needs of glycomics research and biomedical applications. Glycomics study the interactio ns of carbohydrates with other biopolymers, particularly proteins, to gain a better understanding of the roles of carbohydrates in biological processes. This proposed research seeks to develop a new tool for biologists to significantly increase the efficie ncy in glycan anaysis and meet the growing needs of glycomics research and biomedical applications.

Principal Investigator:

Xichun Zhou
3037925615
XICHUNZ@ADATECH.COM

Business Contact:

Sheryl Suhr
sheryls@adatech.com
Small Business Information at Submission:

ADA TECHNOLOGIES, INC.
ADA TECHNOLOGIES, INC. 8100 SHAFFER PKWY, STE 130 LITTLETON, CO 80127

EIN/Tax ID: 840984053
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No