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MICROSCOPY WITH NEUTRON REFRACTIVE LENSES

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
53851
Program Year/Program:
2001 / SBIR
Agency Tracking Number:
1R43CA090172-01
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Adelphi Technology, Inc.
2003 E Bayshore Rd Redwood City, CA 94063-4121
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2001
Title: MICROSCOPY WITH NEUTRON REFRACTIVE LENSES
Agency: HHS
Contract: N/A
Award Amount: $100,000.00
 

Abstract:

DESCRIPTION (Applicant's abstract verbatim): The objective of this proposed research is to construct a prototype neutron microscope capable of imaging biological maternal. By using compound refractive lenses recently developed by Adelphi Technology microscopy is possible with imaging distances in the order of a few meters. Neutron microscopy can be a valuable complement and extension of already mature light, x-ray and electron imaging techniques. Unlike these other sources, neutron propagation in matter is defined by strong neutron-nucleus interaction. Neutrons can provide a means to probe into materials with a completely different "light" allowing visualization of objects otherwise concealed. Biological molecules are ideal for imaging with neutrons, as their hydrocarbon constituents would provide excellent image contrast. Thicker, unstained, unfixed, in vivo samples may be imaged with neutrons since they are less affected by absorption than other sources thus, reducing artifacts created by sample preparation. Also, achievable resolutions of neutron microscopy surpasses those attained with visible light and x-rays, down to few Angstroms making it possible to directly image viruses and genes. The potential for successful development of the prototype imaging system is very high because our preliminary experiment with compound refractive lenses has demonstrated thermal neutron collection and focusing. The research will proceed by optimizing the design of these lenses for imaging and, then, experimentally demonstrating image magnification of biological materials. Neutron microscope designs will include commercially available compact neutron sources for clinical and laboratory use. PROPOSED COMMERCIAL APPLICATION: The development of neutron lens of short focal length would be truly revolutionary since such a lens could be utilized in a large number of applications related to imaging biological materials. Neutron microscopy will permit high-resolution, high-contrast imaging of soft tissue. Unlike x-ray imaging, which achieves contrast with high atomic number atoms, neutron imaging will give contrast with low atomic number materials.

Principal Investigator:

H. R. Beguiristain

Business Contact:


6503287337
CGARY@ADELPHITECH.COM
Small Business Information at Submission:

ADELPHI TECHNOLOGY
2181 PARK BLVD PALO ALTO, CA 94306

EIN/Tax ID: 900215430
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No