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DIAGNOSIS OF NATURAL AND INDUCED DISEASES OF MILITARY IMPORTANCE

Award Information

Agency:
Department of Defense
Branch:
Army
Award ID:
12150
Program Year/Program:
1991 / SBIR
Agency Tracking Number:
12150
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Adeza Biomedical Corpon
1240 Elko Dr Sunnyvale, CA 94089
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 1991
Title: DIAGNOSIS OF NATURAL AND INDUCED DISEASES OF MILITARY IMPORTANCE
Agency / Branch: DOD / ARMY
Contract: N/A
Award Amount: $250,000.00
 

Abstract:

WE PROPOSE TO DEVELOP A SIMPLE, PORTABLE, ONE-STEP ASSAY FOR THE DETECTION OF MYCOPLASMA PNEUMONIAE AND INFLUENZA A WHICH CAN BE PERFORMED INDEPENDENT OF A SOPHISTICATED LABORATORY BY UNTRAINED OR SEMI-SKILLED PERSONNEL. THIS SIMPLE, ONE-STEP METHOD IS CALLED AN OPTICAL BIOASSAY (OBA) AND UTILIZES AN INEXPENSIVE LASER AND PHOTODETECTOR TO DETECT AN ANTIGEN-ANTIBODY BINDING EVENT. ANTIBODY IS COVALENTLY ATTACHED TO A SILICON SURFACE AND TREATED WITH A PROPRIETARY PHOTOLITHOGRAPHIC TECHNIQUE TO PRODUCE ALTERNATING ROWS OF IMMUNOREACTIVE AND NON-IMMUNOREACTIVE ANTIBODY. WHEN A NARROW LASER LIGHT BEAM IS DIRECTED AT THE ANTIBODY COATED SILICON SURFACE, THE LIGHT IS REFLECTED AT ITS INCIDENT ANGLE WITHOUT DIFFRACTION. WHEN ANTIGEN BINDS TO THE IMMUNOREACTIVE (BUT NOT TO THE NONIMMUNOREACTIVE ANTIBODY) A BIOLOGICAL GRID IS CREATED. WHEN LIGHT IS DIRECTED AT THE REACTED SURFACE, THE BIOLOGICAL GRID PRODUCES A DIFFRACTION SIGNAL WHICH IS EASILY DETECTED WITH THE INTENSITY OF THE DIFFRACTION BEING PROPORTIONAL TO THE NUMBER OF SPECIFIC ANTIGEN-ANTIBODY EVENTS ON THE CHIP. FINALLY, THE SOPHISTICATED BUT SIMPLE SYNTHESIS OF MICROELECTRONICS AND BIOTECHNOLOGY MAKES THIS IMMUNODIAGNOSTIC SYSTEM EXTREMELY PORTABLE AND SUITABLE FOR USE IN NON-LABORATORY SETTINGS SUCH AS PHYSICIAN'S OFFICE OR FIELD TESTING.

Principal Investigator:

Dr David E Charlton
4087450975

Business Contact:

Small Business Information at Submission:

Adeza Biomedical
1240 Elko Dr Sunnyvale, CA 94089

EIN/Tax ID:
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No