DESCRIPTION (provided by applicant): The overall goal of this Phase I proposal is to determine the resiliency of platelets during the stabilization process to co-accumulate secondary compounds to enhance their wound healing attributes. This work is based on the extensive documentation of pooled… More

Blood loss due to uncontrolled hemorrhage is a major contribution to at least 90% of the combat death before reaching the field hospital. The ability to control heavy bleeding in the injured soldier is critical and will vastly improve the survival outcome in the theater. Furthermore, complications… More

Blood loss due to uncontrolled hemorrhage is a major contribution to at least 90% of the combat death before reaching the field hospital. The ability to control heavy bleeding in the injured soldier is critical and will vastly improve the survival outcome in the theater. Furthermore, complications… More

Adlyfe Inc. has developed a highly sensitive fluorescence based test, called the Misfolded Protein Diagnostic (MPD) Assay, for the misfolded prion protein associated with infectivity. The femtomolar sensitivity of the test enables the presymptomatic detection in blood, which can be performed ante… More

The main goal of this proposal is to develop stabilized freeze-dried Yucatan pig platelets that will retain the majority of platelet biological properties, but can be stored in the dry state for years. These platelets will be incorporated into a hemostatic dressing that will control bleeding in the… More

The prion disease process involves a conformational change in the prion protein that in turn can serve as the basis for an early detection, diagnostic, prognostic and screening assay. The Misfolded Protein Diagnostic (MPD) Assay detects infectivity in a crude sample through the use of labeled… More