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Development of a hemostatic wound dressing incorporating lyophilized platelets

Award Information

Agency:
Department of Defense
Branch:
Office of the Secretary of Defense
Award ID:
76542
Program Year/Program:
2005 / SBIR
Agency Tracking Number:
O043-H17-3017
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
ADLYFE, INC.
9430 Key West Avenue, Suite 210 Rockville, MD 20850
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2005
Title: Development of a hemostatic wound dressing incorporating lyophilized platelets
Agency / Branch: DOD / OSD
Contract: W81XWH-05-C-0057
Award Amount: $100,000.00
 

Abstract:

The main goal of this proposal is to develop stabilized freeze-dried Yucatan pig platelets that will retain the majority of platelet biological properties, but can be stored in the dry state for years. These platelets will be incorporated into a hemostatic dressing that will control bleeding in the Yucatan pig wound and bone healing model. This proposal is based on the extensive amount of work already performed at Adlyfe, where stored human freeze-drying trehelose-loaded platelets, upon reconstitution with water, demonstrated normal response to physiological agonists as well as able to release growth factors in controlled spatial and temporal manner. In phase I, key structural and functional parameters will be measured in vitro to determine the efficacy of the freeze-dried Yucatan pig platelets as hemostatic agent. These studies will be critical toward the pre-clinical and clinical development of this important hemostat therapeutic proposed for Phase II.

Principal Investigator:

David H. Ho
Senior Scientist
3014248344
dho@adlyfe.com

Business Contact:

Richard Cliff
COO
3014248344
rcliff@adlyfe.com
Small Business Information at Submission:

ADLYFE, INC.
9430 Key West Avenue, Suite 210 Rockville, MD 20850

EIN/Tax ID: 200204901
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No