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PHARMACODYNAMIC ASSAYS FOR CANCER THERAPEUTICS

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
89580
Program Year/Program:
2010 / SBIR
Agency Tracking Number:
CM000051
Solicitation Year:
N/A
Solicitation Topic Code:
NCI
Solicitation Number:
N/A
Small Business Information
Meso Scale Diagnostics
1601 Research Boulevard Rockville, MD 20850-
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 2010
Title: PHARMACODYNAMIC ASSAYS FOR CANCER THERAPEUTICS
Agency: HHS
Contract: N44CO201000075
Award Amount: $756,981.00
 

Abstract:

Pharmacodynamic assays that measure levels of cellular proteins of relevance to cancer will be developed using Meso Scale Diagnostics (MSD) MULTI-ARRAY technology. These assays will be suitable for ¿real time¿ preclinical and clinical sample testing, and should allow rapid evaluation of treatment, responses, gauge treatment correspondence to tumor stasis/regression, allow patient stratification for clinical trials and facilitate clinical validation of cancer therapeutics at early stages of drug development. Assays will be demonstrated in pre-clinical models, namely mouse xenographs of human solid tumors and molecularly characterized cancer cell lines representing different cancer subtypes. Optimized assays will be applied to patient tumor biopsies or surrogate tissues as appropriate, from patients before and after selected drug treatments where possible. The therapeutic agents used will primarily target the PI3k/Akt/mTOR and MAPK signaling pathways, and markers selected are relevant to these pathways. MSD¿s multiplex capability (including measuring total and phosphorylated forms of several targets, exquisite assay sensitivity, minimal sample requirement and wide dynamic ranges make this technology ideally suited to achieving the NCI¿s objectives for molecular pharmacodynamic applications.

Principal Investigator:

Anu Mathew
Small Business Information at Submission:

MESO SCALE DIAGNOSTICS, LLC
9238 GAITHER RD GAITHERSBURG, MD 20877-

EIN/Tax ID: 521974952
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No