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MEASUREMENT OF INTERLEUKIN-2 AND INTERLEUKIN-2 RECEPTOR BY ELISA

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
7078
Program Year/Program:
1987 / SBIR
Agency Tracking Number:
7078
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Advanced Allergy Res Ctrs Inc
10642 Santa Monica Blvd Suite 102 Los Angeles, CA 90025
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1987
Title: MEASUREMENT OF INTERLEUKIN-2 AND INTERLEUKIN-2 RECEPTOR BY ELISA
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

DURING THE PAST 20 YEARS, DIFFERENT BIOLOGICAL ACTIVITIES HAVE BEEN DESCRIBED FOR LYMPHOKINES PRODUCED BY ACTIVATED LEUKOCYTES. INTERLEUKIN-1 (IL-1) IS A FACTOR PRODUCED BY ACTIVATED MONONUCLEAR PHAGOCYTES AND IS ESSENTIAL FOR SUPPORTING BOTH T-CELL AND B-CELL RESPONSES. ACTIVATED T CELLS PRODUCE INTERLEUKIN-2 (IL-2), A FACTOR NECESSARY FOR T-CELL PROLIFERATION. THIS SOLUBLE FACTOR EXERTS ITS BIOLOGICAL EFFECTS BY INTERACTING WITH SPECIFIC HIGH-AFFINITY RECEPTORS ON THE SURFACE OF ACTIVATED T CELLS.A DECREASE IN THE ABILITY TO PRODUCE IL-2 AND DYSFUNCTION OFINTERLEUKIN-2 RECEPTORS (IL-2RS) HAVE BEEN FOUND IN SEVERAL DISEASES, INCLUDING AUTOIMMUNITY, GRAFT VERSUS HOST REJECTION, ACQUIRED IMMUNE DEFICIENCY, LYMPHOADENOPATHY, ANDCANCER. THUS A STRONG RATIONALE EXISTS FOR THE INVESTIGATION OF IL-2 AND IL-2R. PHASE I OF THIS STUDY WILL DEVELOP A SENSITIVE ELISA ASSAY FOR THE MEASUREMENT OF IL-2 AND IL-2R IN THE SAME SAMPLE OF CULTURED LYMPHOCYTES; DETERMINE THE OPTIMAL CONDITIONS FOR THE ASSAY; AND DETERMINE THE SENSITIVITY OF THE ASSAY BY COMPARISON WITH A BIOASSAY. PHASE II WILL INVOLVE THE MEASUREMENT OF IL-2 AND IL-2R IN NORMAL SUBJECTS AND IN PATIENTS WITH CANCER, AIDS, ARTHRITIS, SLE, AND PEMPHIGUS, AS WELL AS IN TRANSPLANTATION SUBJECTS AND OTHERS. WHEN SUFFICIENT CLINICAL DATA HAVE BEEN ACCUMULATED, THE ASSAY WILL BE CONVERTED INTO KIT FORM FOR RESEARCH AND CLINICAL USE.

Principal Investigator:

Vali kermani-arab phd
2134746063

Business Contact:

Small Business Information at Submission:

Advanced Allergy Res Ctrs Inc
10642 Santa Monica Blvd Suite 102 Los Angeles, CA 90025

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No