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SMALL MOLECULE BLOCKERS OF B. ANTHRACIS TOXIN

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
60465
Program Year/Program:
2002 / SBIR
Agency Tracking Number:
AI052894
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
INNOVATIVE BIOLOGICS, INC
INNOVATIVE BIOLOGICS, INC 13455 SUNRISE VALLEY DR, STE 200 HERNDON, VA 20171 3296
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2002
Title: SMALL MOLECULE BLOCKERS OF B. ANTHRACIS TOXIN
Agency: HHS
Contract: 1R43AI052894-01
Award Amount: $106,498.00
 

Abstract:

DESCRIPTION (provided by applicant): The overall goal of this SBIR proposal is the identification of small molecules capable of blocking the cytotoxic action of Bacillus anthracis lethal toxin by blocking the transmembrane pore formed by the protective antigen component of the toxin. Such molecules are envisioned for use as drugs for the treatment of anthrax. The strategy to identify such compounds involves developing an assay for testing the ability of compounds to inhibit the cytotoxic effect of anthrax toxin. A limited representative library of compounds will be designed and synthesized. The synthesized compounds will then be tested for inhibitory activity. The resulting baseline data will be used for computer-assisted design of compounds with improved affinity towards the transmembrane pore, followed by a second round of chemical synthesis and testing.

Principal Investigator:

Vladimir A. Karginov
7039938455
VLADIMIR.KARGINOV@HADRON.COM

Business Contact:

Deborah Hickox
7039934287
DEBORAH.HICKOX@HADRON.COM
Small Business Information at Submission:

ADVANCED BIOSYSTEMS, INC.
ADVANCED BIOSYSTEMS, INC. 10900 UNIVERSITY BLVD MANASSAS, VA 20110

EIN/Tax ID: 113427236
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No